Genetic variability of the hepatitis C virus. Sequence analysis of the NS3 and 5'UTR

1991 ◽  
Vol 13 ◽  
pp. S51
Author(s):  
M Martell ◽  
J Quer ◽  
JI Esteban ◽  
J Genescá ◽  
R Esteban ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sequence Analysis ◽  
Genetic Variability ◽  
Virus Sequence

scholarly journals Use of short tandem repeat fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies

2014 ◽  
Vol 95 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Victoria C. Edwards ◽  
C. Patrick McClure ◽  
Richard J. P. Brown ◽  
Emma Thompson ◽  
William L. Irving ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sequence Analysis ◽  
Molecular Epidemiology ◽  
Alternative Explanation ◽  
Sequence Analyses ◽  
Distinct Virus ◽  
Virus Sequence ◽  
Epidemiology Studies ◽  
Short Tandem

Sequence analysis is used to define the molecular epidemiology and evolution of the hepatitis C virus. Whilst most studies have shown that individual patients harbour viruses that are derived from a limited number of highly related strains, some recent reports have shown that some patients can be co-infected with very distinct variants whose frequency can fluctuate greatly. Whilst co-infection with highly divergent strains is possible, an alternative explanation is that such data represent contamination or sample mix-up. In this study, we have shown that DNA fingerprinting techniques can accurately assess sample provenance and differentiate between samples that are truly exhibiting mixed infection from those that harbour distinct virus populations due to sample mix-up. We have argued that this approach should be adopted routinely in virus sequence analyses to validate sample provenance.

scholarly journals Hepatitis C virus as cause of fulminant hepatitis-sequence analysis of the 5’ nontranslated region

2007 ◽  
Vol 59 (3) ◽  
pp. 37P-38P
Author(s):  
Gorana Stamenkovic ◽  
Milena Bozic ◽  
Snezana Jovanovic-Cupic ◽  
Ksenija Bojovic ◽  
Jasmina Simonovic
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sequence Analysis ◽  
Fulminant Hepatitis ◽  
Nontranslated Region

scholarly journals Sequence analysis of the 5' untranslated region in isolates of at least four genotypes of hepatitis C virus in The Netherlands.

1994 ◽  
Vol 32 (2) ◽  
pp. 306-310 ◽  
Author(s):  
G E Kleter ◽  
L J van Doorn ◽  
J T Brouwer ◽  
S W Schalm ◽  
R A Heijtink ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sequence Analysis ◽  
The Netherlands ◽  
Untranslated Region

Quantification of genotype 4 serum samples: Impact of hepatitis C virus genetic variability

Hepatology ◽  
2010 ◽  
Vol 52 (1) ◽  
pp. 401-401 ◽  
Author(s):  
Philippe Halfon ◽  
Michelle Martinot-Peignoux ◽  
Hacène Khiri ◽  
Patrick Marcellin
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genetic Variability ◽  
Serum Samples ◽  
Genotype 4

scholarly journals Recombinant hepatitis C virus in experimentally infected chimpanzees

2007 ◽  
Vol 88 (1) ◽  
pp. 143-147 ◽  
Author(s):  
Fengxiang Gao ◽  
Omana V. Nainan ◽  
Yuri Khudyakov ◽  
Jinfeng Li ◽  
Ying Hong ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sequence Analysis ◽  
Factor Viii ◽  
Genetic Recombination ◽  
Nucleotide Sequences ◽  
Recombinant Hepatitis ◽  
Rt Pcr ◽  
Crossover Region ◽  
Different Strains

Genetic recombination between different strains of Hepatitis C virus (HCV) was investigated in three chimpanzees inoculated experimentally with factor VIII concentrate containing HCV subgenotypes 1a, 1b, 2b and 3a. A 750 bp long fragment from the HCV envelope region was amplified by RT-PCR and quasispecies were isolated by plasmid cloning. Nucleotide sequences derived from isolated quasispecies were screened for the presence of inter-subgenotypic recombination by using sequence analysis. Recombination between HCV subgenotype 1a and 1b was found in two animals; each recombinant variant differed by location of predicted crossover region or order of subgenotype 1a and 1b sequences.

Refined analysis of genetic variability parameters in hepatitis C virus and the ability to predict antiviral treatment response

2008 ◽  
Vol 15 (8) ◽  
pp. 578-590 ◽  
Author(s):  
J. M. Cuevas ◽  
M. Torres-Puente ◽  
N. Jimnez-Hernndez ◽  
M. A. Bracho ◽  
I. Garca-Robles ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genetic Variability ◽  
Treatment Response ◽  
Antiviral Treatment
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