Combined-modality treatment of small-cell lung cancer: Randomized comparison of three induction chemotherapies followed by maintenance chemotherapy with or without radiotherapy to the chest

Lung Cancer ◽  
1995 ◽  
Vol 12 (3) ◽  
pp. 321
1998 ◽  
Vol 84 (2) ◽  
pp. 259-269 ◽  
Author(s):  
Mauro G. Trovò ◽  
Marco Gigante ◽  
Emilio Minatel ◽  
Carlo Gobitti ◽  
Giovanni Franchin

This paper describes the mechanisms of action of ionizing radiations combined with antineoplastic drugs. Some relevant drugs for the combined modality treatments of locally advanced lung cancer are reported. The meta-analyses including randomized trials comparing single agent (radiotherapy or chemotherapy) versus combined chemoterapy and radiotherapy in patients with unresectable non small cell lung cancer and limited small cell lung cancer are then reviewed. The clinical outcome in relation to different schedules of chemoradiotherapy (sequential, alternating and concurrent) is also focussed.


1984 ◽  
Vol 20 (8) ◽  
pp. 1033-1037 ◽  
Author(s):  
W Bakker ◽  
J.M.A Nijhuis-Heddes ◽  
A.T Van Oosterom ◽  
E.M Noordijk ◽  
J Hermans ◽  
...  

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