Clinical relevance of sonometry-derived tumour thickness in malignant melanoma: a statistical analysis

1995 ◽  
Vol 33 (6) ◽  
pp. 1040-1041
Author(s):  
Mary E Maloney
2006 ◽  
Vol 132 (2) ◽  
pp. 209-214 ◽  
Author(s):  
J. TACKE ◽  
G. HAAGEN ◽  
O.P. HORNSTEIN ◽  
G. HUETTINGER ◽  
F. KIESEWETTER ◽  
...  

Pathology ◽  
1981 ◽  
Vol 13 (4) ◽  
pp. 763-770 ◽  
Author(s):  
Graeme Roberts ◽  
A.L. Martyn ◽  
A.J. Dobson ◽  
W.H. McCarthy

Author(s):  
Alexander Schmidt ◽  
Leona Klussmann ◽  
Maximiliane A. Schlenz ◽  
Bernd Wöstmann

Abstract Objectives Due to the partly strongly differing results in the literature, the aim of the present study was to investigate a possible deformation of the mandible during mouth opening using an intraoral scanner (IOS) and a conventional impression for comparison with a reference aid. Materials and methods Four steel spheres were reversibly luted in the mandibular (n = 50) with a metallic reference aid at maximum mouth opening (MMO). Two digital impressions (Trios3), at MMO and at slightly mouth opening SMO and a conventional impression (Impregum), were taken as the measuring accuracy of the reference structure was already known. Difference between MMO-SMO for digital impressions and deviations between digital and conventional (SMO) were calculated. Furthermore, the angle between the normal vectors of two constructed planes was measured. Statistical analysis was performed with SPSS25. Results Deviations for linear distances ranged from −1 ± 3 μm up to 17 ± 78 μm (digital impressions, MMO-SMO), from 19 ± 16 μm up to 132 ± 90 μm (digital impressions, SMO), and from 28 ± 17 μm up to 60 ± 52 μm (conventional impressions, SMO). There were no significant differences for digital impressions (MMO-SMO), and there were significant differences between the conventional and digital impressions at SMO. Conclusions Based on the results of the present study, no mandibular deformation could be detected during mouth opening with regard to the digital impressions. The results were rather within the measuring tolerance of the intraoral scanner. Clinical relevance Based on the present study, no deformation of the mandibular during mouth opening could be observed at the level previously assumed. Therewith related, dental techniques related to a possible mandibular deformation therefore should be reconsidered.


1984 ◽  
Vol 23 (5) ◽  
pp. 315-320 ◽  
Author(s):  
K. Benediktsdóttier ◽  
M. Edenholm ◽  
Å. Lindholm ◽  
B. Mårtensson ◽  
L. Ståhl ◽  
...  

1998 ◽  
Vol 8 (1) ◽  
pp. 4-7 ◽  
Author(s):  
A. Bobić-Radovanović ◽  
Z. Latković ◽  
J. Marinković ◽  
Z. Radovanović

The study comprised 61 patients with histologically diagnosed malignant melanoma of the conjunctiva (MMC) who were treated and followed up in the Department of Ophthalmology, Clinical Center of Serbia, Belgrade, over a period of 24 years (1970-1993). Data on 15 clinical and 10 histopathological characteristics of MMC were related to the outcome of the disease. Tumour thickness on the histological section was the most important single predictor of survival in MMC. Other predictors of survival in MMC were the number of mitoses, the histologically assessed degree of tumour pigmentation and the intensity of inflammation at the tumour site. The variables entered into the model comprised as much as 85.3% of all predictors of survival in MMC.


1988 ◽  
Vol 41 (4) ◽  
pp. 403-407 ◽  
Author(s):  
Dalia V. Nield ◽  
M.N. Saad ◽  
C.T.K. Khoo ◽  
Margaret Lott ◽  
M.H. Ali

2003 ◽  
Vol 49 (9) ◽  
pp. 1450-1457 ◽  
Author(s):  
Jolanta Szenajch ◽  
Bogdan Jasiński ◽  
Agnieszka Synowiec ◽  
Jadwiga Kulik ◽  
Małgorzata Chomicka ◽  
...  

Abstract Background: The reverse transcription-PCR tyrosinase assay (TYR test) cannot reliably detect malignant melanoma (MM) cells in blood as the cells often circulate at low concentrations. We evaluated the prognostic value of multiple TYR testing, the prognostic significance of individual positive TYR test results (TYR+) in asymptomatic melanoma patients, and whether statistical analysis could help in the interpretation of results of a test that measures phenomena that typically occur below its detection threshold. Methods: MM patients in stages I-IV (n = 150) underwent multiple testing with the TYR test during the course of their disease. TYR testing was performed as described by Smith et al. (Lancet 1991;38:1227–9). Statistical analyses were performed with the logistic function and t-test procedures. Results: The relationship between MM stage and the frequency of TYR+ was statistically significant (P = 0.011). Higher frequency of TYR+ in clinically asymptomatic patients after complete resection of the primary tumor was associated with an increased risk of recurrence of MM (prognostic sensitivity, 62%; specificity, 78%). Conclusions: A single positive TYR test provides a warning for disease relapse, suggesting that multiple TYR testing might provide more reliable predictions of disease progression. Multiple testing and statistical analysis using a logistic function might allow for the interpretation of apparently inconsistent results of tests for very rare cells.


Sign in / Sign up

Export Citation Format

Share Document