Solid-phase synthesis and biological activities of gastrointestinal hormones: Secretin and motilin

Peptides ◽  
1982 ◽  
Vol 3 (2) ◽  
pp. 137-141 ◽  
Author(s):  
David H. Coy ◽  
Esther J. Coy ◽  
Kae-Yol Lee ◽  
William Y. Chey
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Activities ◽  
Gastrointestinal Hormones ◽  
Phase Synthesis

Ampullosporin Analogs: Solid Phase Synthesis, Conformational Studies, and Biological Activities

2001 ◽  
pp. 226-227
Author(s):  
Hoai Huong Nguyen ◽  
Diana Imhof ◽  
Brigitte Schlegel ◽  
Albert Härtl ◽  
Matthias Kronen ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Activities ◽  
Phase Synthesis ◽  
Conformational Studies

Festphasensynthese von Muramyldipeptidderivaten und Untersuchung ihrer biologischen Aktivität / Solid Phase Synthesis of Muramyl Dipeptide Derivatives and Investigations on their Biological Activities

1994 ◽  
Vol 49 (5) ◽  
pp. 702-716 ◽  
Author(s):  
Jochen Tschakert ◽  
Wolfgang Voelter
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Activities ◽  
Muramyl Dipeptide ◽  
Phase Synthesis ◽  
Opsonized Zymosan ◽  
Muramyl Dipeptide Derivatives

New muramyl dipeptide derivatives with exchanged carbohydrate residues are described. Each derivative is synthesized via a solid phase synthesis using an aminomethyl anchor resin. All synthetic products can be isolated in good yields. Their biological activities are tested by the luminol-dependent chemiluminescence associated with the phagocytosis of opsonized zymosan by granulocytes.

Synthesis and biological properties of vasopressin analogues containing 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

1990 ◽  
Vol 55 (4) ◽  
pp. 1099-1105 ◽  
Author(s):  
Zdenko Procházka ◽  
Juris E. Ancans ◽  
Jiřina Slaninová ◽  
Alena Machová ◽  
Tomislav Barth ◽  
...  
Keyword(s):  
Amino Acid ◽  
Carboxylic Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Activities ◽  
Biological Properties ◽  
Phase Synthesis ◽  
Aromatic Residues ◽  
Synthesis Methodology ◽  
Vasopressin Analogues

Solid phase synthesis methodology on a benzhydrylamine resin was used for the synthesis of three analogues of vasopressin with the non-coded amino acid, 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic), in the position 2 ([Tic2, Lys8]VP (I)) and in the position 3 ([Tic3, Lys8]VP (II)). The analogue containing only one Tic in place of both aromatic residues was also isolated (des-Tyr2-[Tic3, Lys8]VP (III)). The biological activities of all analogues were negligible.

Solid phase synthesis and biological activities of oxytocin carba analogues containing threonine in position 4

1985 ◽  
Vol 50 (2) ◽  
pp. 418-427 ◽  
Author(s):  
Michal Lebl ◽  
Victor J. Hruby ◽  
Jiřina Slaninová ◽  
Tomislav Barth
Keyword(s):  
Biological Activity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Activities ◽  
High Biological Activity ◽  
Phase Synthesis

Solis phase methodology was developed for the synthesis of carba-analogues of oxytocin. Two known compounds (deamino-1-carba-oxytocin (I) and deamino-6-carba-oxytocin (II)) and two new analogues ([4-threonine]deamino-1-carba-oxytocin (III) and [4-threonine]deamino-6-carba-oxytocin (IV)) were synthesized using different approaches. The latter two compounds were found to possess high biological activity in the rat uterotonic (in vitro and in vivo) and galactogogic (in vivo) assays.

Solid phase synthesis and biological activities of [Arg8]-vasopressin methylenedithioether

1999 ◽  
Vol 9 (13) ◽  
pp. 1767-1772 ◽  
Author(s):  
Masaaki Ueki ◽  
Takayoshi Ikeo ◽  
Mitsuo Iwadate ◽  
Tetsuo Asakura ◽  
Michael P Williamson ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Activities ◽  
Phase Synthesis
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