Genetic polymorphism of the rat liver aldehyde dehydrogenase and the severity of experimental alcohol-induced liver damage First Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan

Hepatology ◽  
1995 ◽  
Vol 22 (4) ◽  
pp. A244
Keyword(s):  
Internal Medicine ◽  
Genetic Polymorphism ◽  
Rat Liver ◽  
Aldehyde Dehydrogenase ◽  
Liver Damage ◽  
School Of Medicine ◽  
Liver Aldehyde Dehydrogenase

scholarly journals Aldehyde dehydrogenase in 2-acetaminofluorene-induced rat hepatomas. Ontogeny and evidence that the new isoenzymes are not due to normal gene de-repression

1977 ◽  
Vol 164 (1) ◽  
pp. 119-123 ◽  
Author(s):  
Ronald Lindahl
Keyword(s):  
Rat Liver ◽  
Aldehyde Dehydrogenase ◽  
Double Diffusion ◽  
Normal Liver ◽  
Normal Adult ◽  
Sprague Dawley ◽  
Adult Liver ◽  
Aldehyde Dehydrogenases ◽  
Adult Rat ◽  
Liver Aldehyde Dehydrogenase

The pre- and post-natal ontogeny of Sprague–Dawley rat liver aldehyde dehydrogenase [aldehyde–NAD(P)+ oxidoreductase, EC 1.2.1.5] is described. At no time in its ontogenetic development does normal liver aldehyde dehydrogenase exhibit any of the characteristics of a series of unique aldehyde dehydrogenases that can be isolated from 2-acetamidofluorene-induced rat hepatomas. Enzyme activity is first detectable in 15-day foetal liver and gradually increases throughout pre- and post-natal development until adult activities are attained by day 49 after birth. Electrophoretically, normal aldehyde dehydrogenase, throughout its ontogeny, exists as the same single isoenzyme found in normal adult liver. Isoelectric points for two normal liver isoenzymes demonstrable by isoelectric focusing are pH5.9 and 6.0. The immunochemical properties of aldehyde dehydrogenase during its ontogeny are identical with those of normal adult liver aldehyde dehydrogenase when tested against anti-(hepatoma aldehyde dehydrogenase) serum in Ouchterlony double-diffusion tests. The results indicate that the hepatoma-specific aldehyde dehydrogenases are not the result of the de-repression of genes normally repressed in adult rat liver or in some other adult tissue.

Intralobular distribution of rat liver aldehyde dehydrogenase and alcohol dehydrogenase

1988 ◽  
Vol 20 (4) ◽  
pp. 435-437 ◽  
Author(s):  
Hiromi Yamazaki ◽  
Keiko Nishiguchi ◽  
Kyoichi Inoue ◽  
Toshifumi Yasuyama ◽  
Suehiro Nakanishi
Keyword(s):  
Alcohol Dehydrogenase ◽  
Rat Liver ◽  
Aldehyde Dehydrogenase ◽  
Liver Aldehyde Dehydrogenase

ChemInform Abstract: Effects of Cyclopropyl-Containing Amines and Amides on Rat Liver Aldehyde Dehydrogenase Isoforms.

ChemInform ◽  
2010 ◽  
Vol 25 (43) ◽  
pp. no-no
Author(s):  
K. L. KONOPLITSKAYA ◽  
O. V. KISLOVA ◽  
E. G. VINOGRADOVA ◽  
F. F. SHCHERBINA ◽  
A. V. YAZLOVITSKII ◽  
...  
Keyword(s):  
Rat Liver ◽  
Aldehyde Dehydrogenase ◽  
Liver Aldehyde Dehydrogenase

scholarly journals The Role of Positive Charges and Structural Segments in the Presequence of Rat Liver Aldehyde Dehydrogenase in Import into Mitochondria

1996 ◽  
Vol 271 (35) ◽  
pp. 21041-21048 ◽  
Author(s):  
Philip K. Hammen ◽  
Mary Waltner ◽  
Birger Hahnemann ◽  
Thomas S. Heard ◽  
Henry Weiner
Keyword(s):  
Rat Liver ◽  
Aldehyde Dehydrogenase ◽  
Liver Aldehyde Dehydrogenase
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