Cytotoxic activity of 9-β-d-arabinofuranosyl-2-fluoroadenine 5-monophosphate (fludarabine, NSC 312887) in a human tumor cloning system

1988 ◽  
Vol 24 (12) ◽  
pp. 1891-1895 ◽  
Author(s):  
Bernd Lathan ◽  
Volker Diehl ◽  
Gary M. Clark ◽  
Daniel D. von Hoff
Keyword(s):  
Cytotoxic Activity ◽  
Human Tumor ◽  
Cloning System ◽  
Human Tumor Cloning ◽  
Human Tumor Cloning System

Significant activity of a novel cytotoxic agent, LY295501, against a wide range of tumors in the human tumor cloning system

1999 ◽  
Vol 10 (3) ◽  
pp. 303-307 ◽  
Author(s):  
Sami G Diab ◽  
Susan G Hilsenbeck ◽  
Elzbieta Izbicka ◽  
Steven D Weitman ◽  
Daniel D Von Hoff
Keyword(s):  
Human Tumor ◽  
Cytotoxic Agent ◽  
Significant Activity ◽  
Cloning System ◽  
Wide Range ◽  
Human Tumor Cloning ◽  
Human Tumor Cloning System

Evaluation of an amsacrine analog in a human tumor cloning system

1989 ◽  
Vol 24 (4) ◽  
pp. 230-232
Author(s):  
Bernd Lathan ◽  
Daniel D. Von Hoff ◽  
Gary M. Clark ◽  
Edward E. Elslager
Keyword(s):  
Human Tumor ◽  
Cloning System ◽  
Human Tumor Cloning ◽  
Human Tumor Cloning System

Activity of Carbetimer in a human tumor cloning system

1984 ◽  
Vol 2 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Daniel L. Kisner ◽  
Persis Mehta ◽  
G. Edward Paget ◽  
Daniel D. Von Hoff
Keyword(s):  
Human Tumor ◽  
Cloning System ◽  
Human Tumor Cloning ◽  
Human Tumor Cloning System

Application of Sem to The Human Tumor Cloning System

1980 ◽  
Vol 38 ◽  
pp. 776-777
Author(s):  
J. Zeagler ◽  
V. K. Bajpai ◽  
G. Harris ◽  
D. D. Von Hoff
Keyword(s):  
Tumor Cell ◽  
Human Tumor ◽  
Bottom Layer ◽  
Soft Agar ◽  
Feeder Layer ◽  
Biopsy Material ◽  
Tumor Cell Suspension ◽  
Cloning System ◽  
Human Tumor Cloning ◽  
Human Tumor Cloning System

The human tumor cloning system is a two-layer soft agar technique used to grow human tumors directly from biopsy material (1). A nutrient “feeder” layer forms the bottom layer with the tumor-cell-containing layer plated on top. This combination of two-layer plating enables the “feeder” layer to separate the tumor cell suspension from the bottom of the plate and does not allow fibroblasts to attach to dish, which they must do in order to grow.

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