Lack of induced increase in sister chromatid exchanges in human lymphocytes exposed to in vivo therapeutic ultrasound

1 Most hair dyes contain the structural isomers ortho-, meta- and para-aminophenol which were investigated concerning their ability to induce sister chromatid exchanges (SCE) in cultured human lymphocytes in vitro and in Chinese hamster bone marrow cells in vivo. 2 In vitro only ortho-aminophenol significantly induced SCE in a dose-dependent manner. 3 In vivo none of the structural isomers increased significantly the SCE frequency. 4 It is concluded that ortho-aminophenol is a weak directly acting compound which is detoxified during its metabolism.

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Comparative investigations by sister-chromatid exchanges and chromosome aberrations in cultured human lymphocytes of patients under and following in vivo exposure to alkylating chemicals

Mutation Research/Environmental Mutagenesis and Related Subjects ◽

10.1016/0165-1161(82)90094-2 ◽

1982 ◽

Vol 97 (3) ◽

pp. 182 ◽

Cited By ~ 1

Author(s):

M. Dobos ◽

D. Schuler ◽

É. Szakmáry

Keyword(s):

Sister Chromatid ◽

Chromosome Aberrations ◽

Human Lymphocytes ◽

Sister Chromatid Exchanges ◽

Chromatid Exchanges

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Trihalomethanes induce sister chromatid exchanges in human lymphocytes in vitro and mouse bone marrow cells in vivo

Environmental Research ◽

10.1016/0013-9351(83)90193-7 ◽

1983 ◽

Vol 32 (1) ◽

pp. 72-79 ◽

Cited By ~ 53

Author(s):

Kanehisa Morimoto ◽

Akira Koizumi

Keyword(s):

Bone Marrow ◽

Sister Chromatid ◽

Bone Marrow Cells ◽

Human Lymphocytes ◽

Sister Chromatid Exchanges ◽

Mouse Bone Marrow ◽

Chromatid Exchanges ◽

Mouse Bone Marrow Cells

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Assessment of Genotoxicity of Levosimendan in Human Cultured Lymphocytes

Current Molecular Pharmacology ◽

10.2174/1874467212666190306164926 ◽

2019 ◽

Vol 12 (2) ◽

pp. 160-165 ◽

Cited By ~ 1

Author(s):

Abeer M. Rababa'h ◽

Omar F. Khabour ◽

Karem H. Alzoubi ◽

Dua'a Al-momani ◽

Mera Ababneh

Keyword(s):

Dna Damage ◽

Sister Chromatid ◽

Oxidative Dna Damage ◽

Human Lymphocytes ◽

Sister Chromatid Exchanges ◽

In Vivo Studies ◽

Proliferation Index ◽

Chromatid Exchanges ◽

Anti Inflammation

Background and Objective: Levosimendan is a positive inotropic and a vasodilator agent with pleotropic characteristics that include antioxidation, anti-inflammation and smooth muscle vasodilation. Methods: In this study, the effects of levosimendan (0, 0.1, 1, 10, and 20 µg/ml) on oxidative DNA damage and sister-chromatid exchanges (SCEs) were evaluated in human cultured lymphocytes. Results: The results showed that levosimendan increased the frequency of SCEs in all examined concentrations (P<0.01) except for 0.1 µg/ml. On the other hand, levosimendan did not induce oxidative DNA damage as measured by the 8-OHdG biomarker (P > 0.05). In addition, neither mitotic arrest nor proliferation index was affected by levosimendan at all examined doses (P > 0.05). Conclusion: In conclusion, levosimendan might be associated with increases in sister-chromatid exchanges in cultured human lymphocytes. In vivo studies are required to confirm the present findings.

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