Correlation of low blood levels of opioid analgesic fentanyl and modulation of tooth pulp induced jaw opening reflex in the cat

Pain ◽  
1984 ◽  
Vol 18 ◽  
pp. S350
Author(s):  
G. E. Lucier ◽  
M. A. Sabourin ◽  
R. Egizii ◽  
S. H. Roth
Keyword(s):  
Opioid Analgesic ◽  
Tooth Pulp ◽  
Blood Levels ◽  
Jaw Opening ◽  
Jaw Opening Reflex

Excitation and inhibition of neurons in the trigeminal nucleus caudalis following periaqueductal gray stimulation

1978 ◽  
Vol 56 (1) ◽  
pp. 157-161 ◽  
Author(s):  
R. K. Andersen ◽  
J. P. Lund ◽  
E. Puil
Keyword(s):  
Periaqueductal Gray ◽  
Infraorbital Nerve ◽  
Reflex Response ◽  
Tooth Pulp ◽  
Trigeminal Nucleus ◽  
Trigeminal Nucleus Caudalis ◽  
Jaw Opening ◽  
Narcotic Analgesia ◽  
Jaw Opening Reflex ◽  
Decerebrate Cats

Electrical stimulation (3–4 shocks, 300 Hz, 30–150 μA) of the periaqueductal gray matter (CG) or dorsal raphé nucleus (DR) of decerebrate cats reduced or abolished the jaw-opening reflex response evoked by stimulation of either the tooth pulp or infraorbital nerve. In addition, CG or DR stimulation inhibited the response of 12 out of 16 trigeminal nucleus caudalis neurons to activation of their sensory afferent inputs. Ten other neurons recorded in the same sites, and often at the same time, but which did not respond to the sensory inputs utilized, were excited by identical stimuli to CG or DR. This excitatory response was blocked by intravenously administered naloxone (0.1–0.2 mg/kg). It is suggested that those neurons which are excited by CG and DR stimulation may be interneurons involved in pre- and post-synaptic inhibition of sensory transmission during stimulus-produced or narcotic analgesia.

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