If the fourth generation fermions exist, the new quarks could influence the branching ratios of the decays of B→Xsγ and B→Xsl+l-. We obtain two solutions of the fourth generation CKM factor [Formula: see text] from the decay of B→ Xsγ. We use these two solutions to calculate the new contributions of the fourth generation quark to Wilson coefficients of the decay of B→ Xsl+l-. The branching ratio and the forward–backward asymmetry of the decay of B→ Xsl+l- in the two cases are calculated. Our results are quite different from that of SM in one case, almost the same in another case. If Nature chooses the former, the B meson decays could provide a possible test of the fourth generation existence.