High-performance liquid chromatographic determination of nicotinamide in rat tissue samples and blood after extraction with diethyl ether

1987 ◽  
Vol 422 ◽  
pp. 257-262 ◽  
Author(s):  
Katsumi Shibata ◽  
Teruo Kawada ◽  
Kazuo Iwai
Keyword(s):  
Diethyl Ether ◽  
High Performance ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Tissue Samples ◽  
Liquid Chromatographic Determination ◽  
Rat Tissue ◽  
Liquid Chromatographic

High Performance Liquid Chromatographic Determination of Phenothiazine Residues in Sheep Tissues

1980 ◽  
Vol 63 (5) ◽  
pp. 988-991
Author(s):  
Graeme L Blackman ◽  
Ah Chai Ho ◽  
Alex Jozsa ◽  
John D Kelly
Keyword(s):  
High Performance ◽  
Limit Of Detection ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Tissue Samples ◽  
Silica Column ◽  
Liquid Chromatographic Determination ◽  
Residue Levels ◽  
Liquid Chromatographic

Abstract A high performance liquid chromatographic (HPLC) technique is described for the determination of residue levels of the anthelmintic drug phenothiazine in sheep tissues. Phenothiazine was administered to sheep which were slaughtered after withholding periods of 24, 48, and 72 h. Residues of phenothiazine were then extracted from tissue samples by homogenization in methanol. The HPLC analysis of the extracts involved separation on a 10 μm silica column using a mobile phase of 0.3% n-propanol in cyclohexane. The lower limit of detection by ultraviolet absorption at 254 nm was 0.05 ppm

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