Effect of typical and atypical antipsychotic drugs on the in vivo binding of [3H]N-methyl-spiperone to serotonin-2 and dopamine-2 receptors in rat brain

1991 ◽  
Vol 4 (3) ◽  
pp. 326-327 ◽  
Author(s):  
C.A. Stockmeier ◽  
S. Matsubara ◽  
Y. Zhang ◽  
H.Y. Meltzer
Keyword(s):  
Rat Brain ◽  
Atypical Antipsychotic ◽  
Antipsychotic Drugs ◽  
In Vivo Binding ◽  
Atypical Antipsychotic Drugs

Effects of Typical and Atypical Antipsychotic Drugs on Rat Brain Muscarinic Receptors

2007 ◽  
Vol 32 (3) ◽  
pp. 525-532 ◽  
Author(s):  
Katerina Zavitsanou ◽  
Vu H. Nguyen ◽  
Mei Han ◽  
Xu Feng Huang
Keyword(s):  
Rat Brain ◽  
Atypical Antipsychotic ◽  
Muscarinic Receptors ◽  
Antipsychotic Drugs ◽  
Atypical Antipsychotic Drugs

The Importance of Serotonin-Dopamine Interactions in the Action of Clozapine

1992 ◽  
Vol 160 (S17) ◽  
pp. 22-29 ◽  
Author(s):  
Herbert Y. Meltzer
Keyword(s):  
Atypical Antipsychotic ◽  
Atypical Antipsychotics ◽  
Antipsychotic Drugs ◽  
Typical Antipsychotic ◽  
Atypical Antipsychotic Drugs ◽  
Clinical Dose ◽  
High Affinity ◽  
The Relationship

Clozapine has an affinity for the dopamine (DA) D2 receptor which is relatively weak but is in line with its average clinical dose when compared with typical neuroleptic drugs. A few atypical antipsychotic drugs may have high absolute affinities for the D2 receptor, but most are weak D2 blockers. The atypical antipsychotic drugs also differ from the typical antipsychotic drugs by a relatively high affinity for the serotonin (5-HT2) receptor. This is evident on both in vitro and in vivo binding to cortical 5-HT2 receptors. The atypical antipsychotics are best distinguished from the typical antipsychotics on the basis of the relationship between strong 5-HT2 and weak D2 affinities. High D1 receptor binding is not characteristic of the group of atypical drugs. A new group of putative atypical antipsychotic drugs with high affinities for 5-HT2 compared to D2 receptors is under study.

Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT2C receptors in vivo

2002 ◽  
Vol 71 (4) ◽  
pp. 607-613 ◽  
Author(s):  
Vincenzo Di Matteo ◽  
Marisa Cacchio ◽  
Camillo Di Giulio ◽  
Giuseppe Di Giovanni ◽  
Ennio Esposito
Keyword(s):  
Atypical Antipsychotic ◽  
Antipsychotic Drugs ◽  
Biochemical Evidence ◽  
Atypical Antipsychotic Drugs
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