Effects of 6-hydroxydopamine lesions of the medial prefrontal cortex on local cerebral blood flow and D1 and D2 dopamine receptor binding in rats: a quantitative autoradiographic study

1995 ◽  
Vol 5 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Michio Suzuki ◽  
Yasuhiro Kawasaki ◽  
Masahiko Murata ◽  
Ryoko Shibata ◽  
Masayoshi Kurachi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Receptor Binding ◽  
Autoradiographic Study ◽  
D2 Dopamine Receptor ◽  
Local Cerebral Blood Flow ◽  
6 Hydroxydopamine ◽  
Dopamine Receptor Binding

scholarly journals Neuropsychological dysfunction in depression: the relationship to regional cerebral blood flow

1994 ◽  
Vol 24 (4) ◽  
pp. 849-857 ◽  
Author(s):  
R. J. Dolan ◽  
C. J. Bench ◽  
R. G. Brown ◽  
L. C. Scott ◽  
R. S. J. Frackowiak
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Test Performance ◽  
Regional Cerebral Blood Flow ◽  
Brain Regions ◽  
Regional Cerebral Blood ◽  
Neuropsychological Dysfunction ◽  
The Relationship

SynopsisThe relationship between neuropsychological test performance and regional cerebral blood flow (rCBF) was examined in 29 patients meeting Research Diagnostic Criteria (RDC) for major depression. Following a comprehensive neuropsychological assessment two subsets of tests, comprising tests that discriminated between patients and controls or between patients with varying degrees of global cognitive impairment, were selected. These subtests were entered into a principal components analysis (PCA) which generated a two-factor solution, accounting for 50% of the overall variance in test scores. Individual patient loadings on each of these factors were subsequently correlated with regional cerebral blood flow (rCBF), as measured by positron emission tomography (PET). Both factors demonstrated significant correlations with rCBF in the medial prefrontal cortex and frontal polar cortex while for each factor there were also unique patterns of correlations with posterior brain regions. The findings provide additional evidence that neuropsychological deficits in depression are associated with abnormalities in regional brain function and in particular with the function of the medial prefrontal cortex.

scholarly journals Alterations of local cerebral blood flow during hypoxic hypoxia; 14C-iodoantipyrine autoradiographic study.

1984 ◽  
Vol 17 (5) ◽  
pp. 499-506
Author(s):  
RYOICHI SHIMONO ◽  
MASAHISA SHIMADA ◽  
HIROKI S. OZAKI ◽  
TOMIO IMAHAYASHI ◽  
TETUHIDE H. MURAKAMI
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Autoradiographic Study ◽  
Hypoxic Hypoxia ◽  
Local Cerebral Blood Flow
Sign in / Sign up

Export Citation Format

Share Document