EVOLUTIONARY ORIGIN OF ANTIGEN-BINDING POCKETS11Abbreviations. VκL, VλL: Immunoglobulin κK and λ-type light chain variable region. CL : Immunoglobulin light chain constant region. VH : Immunoglobulin heavy chain variable region. CH : Immunoglobulin heavy chain constant region. CDR regions: Complementarity determining regions. MHC antigens: Major histocompatibility antigens.

1986 ◽  
pp. 99-114
Author(s):  
Susumu Ohno
Keyword(s):  
Heavy Chain ◽  
Light Chain ◽  
Variable Region ◽  
Immunoglobulin Heavy Chain ◽  
Antigen Binding ◽  
Constant Region ◽  
Heavy Chain Variable Region ◽  
Major Histocompatibility Antigens ◽  
Heavy Chain Constant Region ◽  
Complementarity Determining Regions

scholarly journals Compensatory Aspects of Allele Diversity at Immunoglobulin Loci: Gene Correlations in Rabbit Populations Devoid of Light Chain Diversity (oryctolagus cuniculus L.; Kerguelen Islands)

Genetics ◽  
1996 ◽  
Vol 144 (3) ◽  
pp. 1181-1194
Author(s):  
Wessel van der Loo ◽  
Patrick Boussès ◽  
Christian P Arthur ◽  
Jean-Louis Chapuis
Keyword(s):  
Heavy Chain ◽  
Negative Correlation ◽  
Light Chain ◽  
Variable Region ◽  
Significant Negative Correlation ◽  
Selective Advantage ◽  
Constant Region ◽  
B Locus ◽  
Heavy Chain Constant Region ◽  
Excess Heterozygosity

Abstract Is there a selective advantage of increased diversity at one immunoglobulin locus when diversity at another locus is low? A previous paper demonstrated excess heterozygosity at the rabbit light chain b locus when heterozygosity was low at the heavy chain constant region e locus. Here we consider the reverse situation by analyzing allele distributions at heavy chain loci in populations fixed for the light chain b locus. We analyzed the a locus that encodes the predominantly expressed heavy chain variable region, and the d and e loci that control different parts of the Ig gamma class constant region. While there was excess heterozygosity, genetic differentiation between localities was extensive and was most pronounced for females. This was in marked contrast with observations in areas where b-locus diversity was important and confirms a negative correlation between e- and b-locus heterozygosity. Trigenic disequilibria corresponded to a significant negative correlation between e- and a-locus heterozygosity due mainly to strong variation among localities within the context of pronounced (digenic) linkage disequilibria. Although substantial, the average increase in a/e-locus single heterozygosity implemented by higher order disequilibria within localities was not significant.

Development of diagnostic antibodies against immunoglobulin heavy chain variable region for heavy chain amyloidosis (AH amyloidosis)

2021 ◽  
Vol 71 (4) ◽  
pp. 245-254
Author(s):  
Mayuko Nakagawa ◽  
Masahide Yazaki ◽  
Fuyuki Kametani ◽  
Nagaaki Katoh ◽  
Tsuneaki Yoshinaga ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Variable Region ◽  
Immunoglobulin Heavy Chain ◽  
Heavy Chain Variable Region

scholarly journals Physical Mapping of the Bovine Immunoglobulin Heavy Chain Constant Region Gene Locus

2003 ◽  
Vol 278 (37) ◽  
pp. 35024-35032 ◽  
Author(s):  
Yaofeng Zhao ◽  
Imre Kacskovics ◽  
Hodjattallah Rabbani ◽  
Lennart Hammarström
Keyword(s):  
Heavy Chain ◽  
Physical Mapping ◽  
Gene Locus ◽  
Immunoglobulin Heavy Chain ◽  
Constant Region ◽  
Region Gene ◽  
Constant Region Gene ◽  
Heavy Chain Constant Region ◽  
Bovine Immunoglobulin
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