Introduction and Overview of Clinical Computing Systems within a Medical Center

Author(s):  
Thomas H. Payne
1993 ◽  
Vol 32 (02) ◽  
pp. 167-174 ◽  
Author(s):  
D. F. Sittig

Abstract:An increasing number of health-care institutions are in the process of implementing clinical computing systems. The need for an accurate assessment of the clinical, administrative, social, and financial effects of such systems has been recognized. Techniques have been developed to evaluate these effects on the work patterns of health-care workers including: time-motion analysis, subjective evaluations, review of departmental statistics, personal activity records, and work-sampling. This study reviews these techniques, discusses both positive and negative aspects, and presents a step-by-step description of work-sampling.


Author(s):  
Douglas L. Dorset ◽  
Barbara Moss

A number of computing systems devoted to the averaging of electron images of two-dimensional macromolecular crystalline arrays have facilitated the visualization of negatively-stained biological structures. Either by simulation of optical filtering techniques or, in more refined treatments, by cross-correlation averaging, an idealized representation of the repeating asymmetric structure unit is constructed, eliminating image distortions due to radiation damage, stain irregularities and, in the latter approach, imperfections and distortions in the unit cell repeat. In these analyses it is generally assumed that the electron scattering from the thin negativelystained object is well-approximated by a phase object model. Even when absorption effects are considered (i.e. “amplitude contrast“), the expansion of the transmission function, q(x,y)=exp (iσɸ (x,y)), does not exceed the first (kinematical) term. Furthermore, in reconstruction of electron images, kinematical phases are applied to diffraction amplitudes and obey the constraints of the plane group symmetry.


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