The Mechanism of Action of Adrenocorticotropic Hormone on Cholesterol Metabolism in the Adrenal Cortex

Author(s):  
Robert C. Pedersen ◽  
Alexander C. Brownie
1967 ◽  
Vol 242 (23) ◽  
pp. 5535-5541 ◽  
Author(s):  
D.G. Grahame-Smith ◽  
R.W. Butcher ◽  
R.L. Ney ◽  
Earl W. Sutherland

1971 ◽  
Vol 246 (17) ◽  
pp. 5407-5413
Author(s):  
Hideo Masui ◽  
Leonard D. Garren

1965 ◽  
Vol 43 (9) ◽  
pp. 1489-1498 ◽  
Author(s):  
Edward E. Nishizawa ◽  
R. B. Billiar ◽  
J. Karr ◽  
Kristen B. Eik-Nes

Adrenocorticotrophic hormone (ACTH) labeled with tritium has been prepared with a specific radioactivity of approximately 4000 d.p.m./μg. The tritiated trophin showed biological activity and appeared to be bound to the cells of the adrenal gland. Data indicating that the adrenal cortex can inactivate ACTH were obtained; whether such inactivation is due to binding or enzymatic degradation has not been illustrated. Attempts to demonstrate that the adrenal gland could acetylate the N-terminal serine residue of ACTH failed.


1993 ◽  
Vol 40 (2) ◽  
pp. 221-225 ◽  
Author(s):  
TETSUO NISHIKAWA ◽  
KEIJI MIKAMI ◽  
AKIKO YOSHIDA ◽  
MASAO OMURA ◽  
YASUSHI TAMURA ◽  
...  

1993 ◽  
Vol 40 (4) ◽  
pp. 453-459 ◽  
Author(s):  
TETSUO NISHIKAWA ◽  
KEIJI MIKAMI ◽  
AKIKO YOSHIDA ◽  
MASAO OMURA ◽  
YASUSHI SAITO ◽  
...  

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