Preclinical and Clinical Experiences with Drug Combinations Designed to Inhibit DNA Repair in Resistant Human Tumor Cells

Mechanisms of Drug Resistance in Neoplastic Cells ◽

10.1016/b978-0-12-763362-6.50018-2 ◽

1988 ◽

pp. 173-182 ◽

Author(s):

LEONARD C. ERICKSON ◽

KENNETH C. MICETICH ◽

RICHARD I. FISHER

Keyword(s):

Tumor Cells ◽

Human Tumor ◽

Drug Combinations ◽

Clinical Experiences ◽

Human Tumor Cells

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Abstract C77: A novel BRCA2 targeting antisense oligonucleotide sensitizes human tumor cells to chemotherapy and radiotherapy - the induction of ‘complementary lethality’ by targeting DNA repair.

10.1158/1535-7163.targ-13-c77 ◽

2013 ◽

Author(s):

Mateusz Rytelewski ◽

Jessica Tong ◽

Adrian Buensucesco ◽

Saman Maleki Vareki ◽

Peter J. Ferguson ◽

...

Keyword(s):

Tumor Cells ◽

Antisense Oligonucleotide ◽

Human Tumor ◽

Human Tumor Cells

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Abstract 3314: Sensitization of human tumor cells to chemotherapy drugs by antisense downregulation of BRCA2 and thymidylate synthase (TS): Induction of synthetic lethality by targeting DNA repair.

10.1158/1538-7445.am2013-3314 ◽

2013 ◽

Author(s):

Peter J. Ferguson ◽

Mateusz Rytelewski ◽

Mark D. Vincent ◽

René Figueredo ◽

James Koropatnick

Keyword(s):

Tumor Cells ◽

Thymidylate Synthase ◽

Synthetic Lethality ◽

Human Tumor ◽

Human Tumor Cells ◽

Chemotherapy Drugs

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Specific DNA repair mechanisms may protect some human tumor cells from DNA interstrand crosslinking by chloroethylnitrosoureas but not from crosslinking by other anti-tumor alkylating agents

Carcinogenesis ◽

10.1093/carcin/6.3.445 ◽

1985 ◽

Vol 6 (3) ◽

pp. 445-450 ◽

Author(s):

Neil W. Gibson ◽

Chana Zlotogorski ◽

Leonard C. Erickson

Keyword(s):

Tumor Cells ◽

Alkylating Agents ◽

Human Tumor ◽

Human Tumor Cells ◽

Dna Repair Mechanisms ◽

Repair Mechanisms ◽

Interstrand Crosslinking

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Abstract 1106: Targeting both non-coding and coding sequences with small RNA efficiently knocks down DNA repair genes and radiosensitizes human tumor cells

10.1158/1538-7445.am2012-1106 ◽

2012 ◽

Author(s):

Zhiming Zheng ◽

Ya Wang ◽

Xiangming Zhang

Keyword(s):

Tumor Cells ◽

Small Rna ◽

Human Tumor ◽

Dna Repair Genes ◽

Human Tumor Cells ◽

Coding Sequences ◽

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Abstract 3718: Sensitization of human tumor cells to chemotherapy drugs by antisense downregulation of RAD51: Targeting DNA repair to induce synthetic lethality

10.1158/1538-7445.am2016-3718 ◽

2016 ◽

Author(s):

Peter J. Ferguson ◽

Mateusz Rytelewski ◽

Mark D. Vincent ◽

James Koropatnick

Keyword(s):

Tumor Cells ◽

Synthetic Lethality ◽

Human Tumor ◽

Human Tumor Cells ◽

Chemotherapy Drugs

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Abstract 871: Dual inhibition of PI3K and Erk1/2 shows synergy and efficacy in human tumor cells, either by using drug combinations or novel dual PI3K/Erk inhibitors

10.1158/1538-7445.am2012-871 ◽

2012 ◽

Author(s):

Irene Seipelt ◽

Matthias Gerlach ◽

Lars Blumenstein ◽

Gilbert Mueller ◽

Eckhard Guenther ◽

...

Keyword(s):

Tumor Cells ◽

Human Tumor ◽

Drug Combinations ◽

Human Tumor Cells ◽

Dual Inhibition

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RNAi-Mediated Targeting of Noncoding and Coding Sequences in DNA Repair Gene Messages Efficiently Radiosensitizes Human Tumor Cells

Cancer Research ◽

10.1158/0008-5472.can-11-2785 ◽

2012 ◽

Vol 72 (5) ◽

pp. 1221-1228 ◽

Author(s):

Zhiming Zheng ◽

Wooi Loon Ng ◽

Xiangming Zhang ◽

Jeffrey J. Olson ◽

Chunhai Hao ◽

...

Keyword(s):

Tumor Cells ◽

Human Tumor ◽

Human Tumor Cells ◽

Repair Gene ◽

Coding Sequences ◽

Dna Repair Gene

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Quantitation of DNA repair capacities of human tumor cells by estimation of transfer of DNA adducts to repair proteins

Pharmacology & Therapeutics ◽

10.1016/0163-7258(85)90041-5 ◽

1985 ◽

Vol 31 (1-2) ◽

pp. 141-151 ◽

Author(s):

Daniel B. Yarosh

Keyword(s):

Tumor Cells ◽

Dna Adducts ◽

Human Tumor ◽

Human Tumor Cells

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The embryonic-like properties of aggressive human tumor cells

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(01)00147-2 ◽

2002 ◽

Vol 9 (1) ◽

pp. 2-9 ◽

Author(s):

A Sood

Keyword(s):

Tumor Cells ◽

Human Tumor ◽

Human Tumor Cells

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Creating human tumor cells

Nature ◽

10.1038/news990729-7 ◽

1999 ◽

Author(s):

Hannah Wunsch

Keyword(s):

Tumor Cells ◽

Human Tumor ◽

Human Tumor Cells

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