interstrand crosslinking
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Destabilization of DNA through interstrand crosslinking by UO22+

2019 ◽  
Vol 55 (14) ◽  
pp. 2015-2018 ◽  
Author(s):  
André Rossberg ◽  
Takaya Abe ◽  
Koji Okuwaki ◽  
Astrid Barkleit ◽  
Kaori Fukuzawa ◽  
...  
Keyword(s):  
Dna Molecule ◽  
Interstrand Crosslink ◽  
Single Dna Molecule ◽  
Interstrand Crosslinking

UO22+ was shown to form an interstrand crosslink between two different strands of a single DNA molecule.

scholarly journals ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies

Blood ◽  
2018 ◽  
Vol 131 (10) ◽  
pp. 1094-1105 ◽  
Author(s):  
Francesca Zammarchi ◽  
Simon Corbett ◽  
Lauren Adams ◽  
Peter C. Tyrer ◽  
Konstantinos Kiakos ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Hematological Malignancies ◽  
Minor Groove ◽  
Clinical Development ◽  
Antibody Drug Conjugate ◽  
Dna Minor Groove ◽  
Drug Conjugate ◽  
Key Points ◽  
Interstrand Crosslinking ◽  
Antibody Drug

Key Points ADCT-402 is a CD19-targeted ADC delivering SG3199, a cytotoxic DNA minor groove interstrand crosslinking PDB dimer warhead. ADCT-402 has potent and selective antitumor activity against CD19-expressing hematological malignancies warranting clinical development.

scholarly journals Interstrand DNA covalent binding of two dinuclear Ru(ii) complexes. Influence of the extra ring of the bridging ligand on the DNA interaction and cytotoxic activity

2017 ◽  
Vol 46 (11) ◽  
pp. 3611-3622 ◽  
Author(s):  
Héctor J. Lozano ◽  
Natalia Busto ◽  
Gustavo Espino ◽  
Arancha Carbayo ◽  
José M. Leal ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Covalent Binding ◽  
Dna Interaction ◽  
Bridging Ligand ◽  
Interstrand Crosslinking

The quinones naphthazarin and quinizarin intercalate into DNA whereas their p-cymene di-ruthenium(ii) complexes bind covalently via interstrand crosslinking.

Porphyrin-based photosensitizers and their DNA conjugates for singlet oxygen induced nucleic acid interstrand crosslinking

2017 ◽  
Vol 15 (25) ◽  
pp. 5402-5409 ◽  
Author(s):  
Eva M. Llamas ◽  
João P. C. Tome ◽  
João M. M. Rodrigues ◽  
Tomás Torres ◽  
Annemieke Madder
Keyword(s):  
Nucleic Acid ◽  
Singlet Oxygen ◽  
Red Light ◽  
Dna Conjugates ◽  
Interstrand Crosslink ◽  
Interstrand Crosslinking

Porphyrin-based photosensitisers and their DNA conjugates have been evaluated for interstrand crosslink generation using furan containing oligonucleotides and red light.

scholarly journals Complementation of hypersensitivity to DNA interstrand crosslinking agents demonstrates thatXRCC2is a Fanconi anaemia gene

2016 ◽  
Vol 53 (10) ◽  
pp. 672-680 ◽  
Author(s):  
Jung-Young Park ◽  
Elizabeth L Virts ◽  
Anna Jankowska ◽  
Constanze Wiek ◽  
Mohamed Othman ◽  
...  
Keyword(s):  
Fanconi Anaemia ◽  
Interstrand Crosslinking ◽  
Crosslinking Agents

scholarly journals A clickable psoralen to directly quantify DNA interstrand crosslinking and repair

2016 ◽  
Vol 24 (5) ◽  
pp. 1071-1078 ◽  
Author(s):  
Benjamin J. Evison ◽  
Marcelo L. Actis ◽  
Naoaki Fujii
Keyword(s):  
Interstrand Crosslinking

scholarly journals Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

2016 ◽  
Vol 52 (42) ◽  
pp. 6930-6933 ◽  
Author(s):  
A. Manicardi ◽  
E. Gyssels ◽  
R. Corradini ◽  
A. Madder
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Double Stranded Dna ◽  
Dna Strand ◽  
Interstrand Crosslinking

Furan-modified peptide nucleic acid (PNA) probes are able to crosslink to DNA strand after hybridization with complementary ssDNA or after stand displacement in dsDNA.

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