Musculoskeletal tissue chips

2022 ◽  
pp. 275-304
Author(s):  
Anne Yau ◽  
Kaitlyn Yeh ◽  
Yupeng Chen
Keyword(s):  
Musculoskeletal Tissue

Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders

2021 ◽  
pp. 2100217
Author(s):  
Itsasne Erezuma ◽  
Tatiane Eufrasio‐da‐Silva ◽  
Nasim Golafshan ◽  
Kaivalya Deo ◽  
Yogendra Kumar Mishra ◽  
...  
Keyword(s):  
Musculoskeletal Tissue

scholarly journals Surface-directed engineering of tissue anisotropy in microphysiological models of musculoskeletal tissue

2021 ◽  
Vol 7 (11) ◽  
pp. eabe9446 ◽  
Author(s):  
Mark J. Mondrinos ◽  
Farid Alisafaei ◽  
Alex Y. Yi ◽  
Hossein Ahmadzadeh ◽  
Insu Lee ◽  
...  
Keyword(s):  
Muscle Injury ◽  
Cancer Cachexia ◽  
Myogenic Differentiation ◽  
Mechanical Anisotropy ◽  
Musculoskeletal Tissue ◽  
Boundary Constraints ◽  
Cell Contractility ◽  
Engineered Tissue ◽  
Tissue Anisotropy

Here, we present an approach to model and adapt the mechanical regulation of morphogenesis that uses contractile cells as sculptors of engineered tissue anisotropy in vitro. Our method uses heterobifunctional cross-linkers to create mechanical boundary constraints that guide surface-directed sculpting of cell-laden extracellular matrix hydrogel constructs. Using this approach, we engineered linearly aligned tissues with structural and mechanical anisotropy. A multiscale in silico model of the sculpting process was developed to reveal that cell contractility increases as a function of principal stress polarization in anisotropic tissues. We also show that the anisotropic biophysical microenvironment of linearly aligned tissues potentiates soluble factor-mediated tenogenic and myogenic differentiation of mesenchymal stem cells. The application of our method is demonstrated by (i) skeletal muscle arrays to screen therapeutic modulators of acute oxidative injury and (ii) a 3D microphysiological model of lung cancer cachexia to study inflammatory and oxidative muscle injury induced by tumor-derived signals.

Infections Transmitted through Musculoskeletal-Tissue Allografts

2004 ◽  
Vol 350 (25) ◽  
pp. 2544-2546 ◽  
Author(s):  
Robin Patel ◽  
Andrej Trampuz
Keyword(s):  
Musculoskeletal Tissue

Infrared fiber optic probes for evaluation of musculoskeletal tissue pathology

2014 ◽  
Author(s):  
Mugdha Padalkar ◽  
Cushla McGoverin ◽  
Quam Onigbanjo ◽  
Richard Spencer ◽  
Scott Barbash ◽  
...  
Keyword(s):  
Fiber Optic ◽  
Musculoskeletal Tissue ◽  
Fiber Optic Probes

Biomimetic strategies for fabricating musculoskeletal tissue scaffolds: a review

2021 ◽  
Author(s):  
Yingge Zhou ◽  
Dilshan Sooriyaarachchi ◽  
Defu Liu ◽  
George Z. Tan
Keyword(s):  
Tissue Scaffolds ◽  
Musculoskeletal Tissue

scholarly journals Systematic Review of Silk Scaffolds in Musculoskeletal Tissue Engineering Applications in the Recent Decade

2021 ◽  
Vol 7 (3) ◽  
pp. 817-840 ◽  
Author(s):  
Li Zhang ◽  
Wei Zhang ◽  
Yejun Hu ◽  
Yang Fei ◽  
Haoyang Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Tissue Engineering ◽  
Recent Decade ◽  
Engineering Applications ◽  
Musculoskeletal Tissue ◽  
Silk Scaffolds

scholarly journals The coming of age of musculoskeletal tissue engineering

2013 ◽  
Vol 9 (2) ◽  
pp. 74-76 ◽  
Author(s):  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Coming Of Age ◽  
Musculoskeletal Tissue
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