Deamidated gliadin peptide and tissue transglutaminase antibodies in children with coeliac disease: A correlation study

2020 ◽  
Vol 21 (3) ◽  
pp. 174-178
Author(s):  
Omar I. Saadah ◽  
Aisha M. Alamri ◽  
Jamil A. Al-Mughales
Keyword(s):  
Coeliac Disease ◽  
Tissue Transglutaminase ◽  
Correlation Study ◽  
Gliadin Peptide ◽  
Tissue Transglutaminase Antibodies

A comparative study of tissue transglutaminase antibodies and endomysium antibody immunofluorescence in routine clinical laboratory practice

2003 ◽  
Vol 40 (4) ◽  
pp. 411-416 ◽  
Author(s):  
David Sinclair ◽  
Callum B Pearce ◽  
Michael S. L. Saas ◽  
David Poller
Keyword(s):  
Guinea Pig ◽  
Coeliac Disease ◽  
Clinical Laboratory ◽  
Tissue Transglutaminase ◽  
Iga Deficiency ◽  
Complete Agreement ◽  
Tissue Transglutaminase Antibodies ◽  
Routine Clinical Laboratory ◽  
Endomysium Antibodies ◽  
Human Source

Background: The demand for screening for coeliac disease has grown rapidly over the last few years. Laboratories depending on immunofluorescence assays are faced with an increasing workload using a labour-intensive test, and an alternative to this test has been sought. This study compares tissue transglutaminase (TTG) and endomysium antibodies (EMA) in a routine clinical laboratory situation. Methods: An immunofluorescence IgA EMA test was compared with a guinea pig TTG antibody ELISA for 816 unselected requests for gut antibody screening. Discrepant results were investigated more fully using a variety of human source TTG antigen kits. Results: Guinea pig TTG ELISA and EMA assays showed agreement for 93·6% of samples. Four samples were misclassified and 48 samples gave false positive TTG results. Study of 46 EMA samples (this group included 39 of the 'discrepant' negative EMA/positive guinea pig TTG group) using three different human purified and/or recombinant TTG sources showed that 42 patients had no TTG antibodies using human sources, three were misclassified and one patient had negative EMA and positive TTG results that could not be readily explained. Further study of 32 EMA positive samples showed almost complete agreement between the human source TTG kits. Conclusions: We can recommend the replacement of EMA with ELISA for TTG antibodies for the routine screening for coeliac disease, but all positive TTG antibodies should still be followed up with IgA EMA and samples should be screened for IgA deficiency.

IgA class anti-endomysial and anti-tissue transglutaminase antibodies in relation to duodenal mucosa changes in coeliac disease

Pathology ◽  
2003 ◽  
Vol 35 (1) ◽  
pp. 56-60 ◽  
Author(s):  
Lorete Maria da Silva Kotze ◽  
Shirley Ramos da Rosa Utiyama ◽  
Renato Mitsunori Nisihara ◽  
Vanessa Ferreira de Camargo ◽  
Sergio Ossamu Ioshii
Keyword(s):  
Coeliac Disease ◽  
Tissue Transglutaminase ◽  
Duodenal Mucosa ◽  
Tissue Transglutaminase Antibodies

Anti-Tissue Transglutaminase Antibodies in Patients with Abnormal Liver Tests: Is It Always Coeliac Disease?

2005 ◽  
Vol 100 (11) ◽  
pp. 2472-2477 ◽  
Author(s):  
Oreste Lo Iacono ◽  
Salvatore Petta ◽  
Giovanna Venezia ◽  
Vito Di Marco ◽  
Giuseppe Tarantino ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Tissue Transglutaminase ◽  
Tissue Transglutaminase Antibodies ◽  
Liver Tests

scholarly journals Anti-tissue transglutaminase antibodies in the follow-up of adult coeliac disease

2009 ◽  
Vol 30 (3) ◽  
pp. 236-244 ◽  
Author(s):  
C. R. DIPPER ◽  
S. MAITRA ◽  
R. THOMAS ◽  
C. A. LAMB ◽  
A. P. C. MCLEAN-TOOKE ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Tissue Transglutaminase ◽  
Tissue Transglutaminase Antibodies
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