Photoreceptor layer features in eyes with closed macular holes: Optical coherence tomography findings and correlation with visual outcomes

Purpose: Epiretinal membrane (ERM) is a common retinal finding for patients older than 50 years. Disorganization of the retinal inner layers (DRIL) has emerged as a novel predictor of poor visual acuity (VA) in eyes with inner retinal pathology. The aim of our study is to correlate preoperative DRIL with visual outcomes after ERM surgery. Methods: Medical records and optical coherence tomography (OCT) images of 81 pseudophakic patients who underwent treatment of idiopathic ERM were reviewed. Preoperative DRIL on OCT was correlated with VA at baseline and at 3 and 6 months after ERM surgery. DRIL was defined as the loss of distinction between the ganglion cell–inner plexiform layer complex, inner nuclear layer, and outer plexiform layer. DRIL severity was based on its extent within the central 2-mm region of a transfoveal B-scan (absent/mild: <one-third, severe: >one-third horizontal width). Results: Review of preoperative OCT showed severe DRIL in 41% and absent/mild DRIL in 59%. Severe DRIL was associated with worse baseline VA ( P < .001). Preoperative VA and DRIL status at baseline were both predictors of postoperative VA at follow-up time points ( P < .001). Severe DRIL was associated with significantly less improvement in VA at 6 months (–0.23 logMAR for absent/mild vs –0.14 for severe DRIL). Conclusions: Presence of severe preoperative DRIL correlates with worse baseline VA in patients with ERM and reduced VA improvement at 6 months. DRIL can be a strong predictor of long-term poor visual outcomes in ERM surgery.

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QUANTIFICATION OF PHOTORECEPTOR LAYER THICKNESS IN NORMAL EYES USING OPTICAL COHERENCE TOMOGRAPHY

Retina ◽

10.1097/01.iae.0000236468.33325.74 ◽

2006 ◽

Vol 26 (6) ◽

pp. 655-660 ◽

Cited By ~ 2

Author(s):

ANNIE CHAN ◽

JAY S. DUKER ◽

HIROSHI ISHIKAWA ◽

TONY H. KO ◽

JOEL S. SCHUMAN ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Layer Thickness ◽

Optical Coherence ◽

Photoreceptor Layer

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Analysis of the ganglion cell layer and photoreceptor layer using optical coherence tomography after idiopathic epiretinal membrane surgery

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-014-2684-5 ◽

2014 ◽

Vol 253 (2) ◽

pp. 207-214 ◽

Cited By ~ 9

Author(s):

Sung Who Park ◽

Ik Soo Byon ◽

Ho Yun Kim ◽

Ji Eun Lee ◽

Boo Sup Oum

Keyword(s):

Optical Coherence Tomography ◽

Ganglion Cell ◽

Epiretinal Membrane ◽

Ganglion Cell Layer ◽

Cell Layer ◽

Optical Coherence ◽

Idiopathic Epiretinal Membrane ◽

Photoreceptor Layer

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Optical Coherence Tomography Findings in Idiopathic Macular Holes

Journal of Ophthalmology ◽

10.1155/2011/928205 ◽

2011 ◽

Vol 2011 ◽

pp. 1-4 ◽

Cited By ~ 5

Author(s):

Lynn L. Huang ◽

David H. Levinson ◽

Jonathan P. Levine ◽

Umar Mian ◽

Irena Tsui

Keyword(s):

Optical Coherence Tomography ◽

Macular Hole ◽

Clinical Assessment ◽

Chart Review ◽

Subretinal Fluid ◽

Optical Coherence ◽

Cross Sectional ◽

Macular Holes ◽

Idiopathic Macular Holes ◽

Intraretinal Cysts

Purpose. To describe the characteristics of idiopathic macular holes (MH) on optical coherence tomography (OCT) and correlate OCT with clinical assessment.Design. Cross-sectional chart review and OCT assessment.Participants. Sixty-seven eyes with a clinically diagnosed idiopathic MH with available OCT data.Methods. A retrospective chart review and OCT assessment.Results. Based on OCT grading, 40 eyes had a full-thickness macular hole (FTMH) and 21 eyes had a lamellar macular hole (LMH). Clinical exam and OCT assessment agreed in 53 (87%) eyes when assessing the extent of MH. Six eyes (14.6%) in the FTMH group, and 3 eyes in the LMH group (14.3%) had persistent vitreomacular traction. Thirty-seven eyes (92.5%) in the FTMH group and 11 eyes (52.4%) in the LMH group had associated intraretinal cysts. Two eyes (5.0%) in the FTMH group and zero eyes in the LMH group had subretinal fluid. Intraretinal cysts were found to be more frequently associated with FTMH than with LMH (P<0.001).Conclusion. This paper described OCT findings in a group of patients with clinically diagnosed MH. A high level of correlation between clinical assessment and OCT findings of LMH and FTMH was observed, and intraretinal cysts were often present in FTMH.

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Optical coherence tomography assessment for attached posterior vitreous in eyes with macular holes and epiretinal membranes

Clinical and Experimental Vision and Eye Research ◽

10.15713/ins.clever.5 ◽

2018 ◽

Vol 1 (1) ◽

pp. 18-22

Author(s):

Petros Aristodemou ◽

Marten E. Brelen ◽

Nishant Kumar ◽

Richard Markham ◽

Richard J. Haynes ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence ◽

Epiretinal Membranes ◽

Macular Holes

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Enhanced vitreous imaging optical coherence tomography in primary macular holes

International Ophthalmology ◽

10.1007/s10792-015-0126-y ◽

2015 ◽

Vol 36 (3) ◽

pp. 355-363 ◽

Cited By ~ 8

Author(s):

Atsushi Takahashi ◽

Taiji Nagaoka ◽

Akitoshi Yoshida

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence ◽

Macular Holes ◽

Imaging Optical Coherence Tomography

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Morphofunctional analysis of the retina in the surgical treatment of idiopathic macular holes

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-3-48-52 ◽

2021 ◽

pp. 48-52

Author(s):

A.S. Zotov ◽

◽

A.S. Balalin ◽

S.V. Balalin ◽

S.M. Purshak ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Surgical Treatment ◽

Macular Hole ◽

Practical Importance ◽

Functional Results ◽

Hole Diameter ◽

Optical Coherence ◽

Macular Holes ◽

Idiopathic Macular Holes ◽

Morphofunctional Analysis

Purpose. To evaluate the role of microperimetry and optical coherence tomography (OCT) in the morphofunctional analysis of the retina after surgical treatment of idiopathic macular holes (IMH). Materials and methods. A retrospective study of 33 patient's treatment results (33 eyes) with IMH was carried out. All patients underwent minimally invasive with 25G or 27G vitrectomy. Best corrected visual acuity (BCVA), macular photosensitivity, fixation stability, macular neuroepithelial (NE) volume and minimal macular hole diameter were analyzed. Follow-up period: 6 months. Results. A complete closure of the macular hole was achieved in all cases post-op. The patients had reliable improvement of BCVA, retinal photosensitivity and decrease of macular NE volume. Based on a multifactor correlation analysis with the purpose to predict the results of surgical treatment, the dependence of post-op BCVA on the pre-op photosensitivity of the retina and the minimal diameter of the macular hole was revealed. Conclusions. Microperimetry and OCT are modern non-invasive research methods allowing to estimate anatomical and functional results of surgical IMH treatment. The study of retinal photosensitivity in the macula and minimal macular hole diameter pre-op allows to predict post-op BCVA, which has a practical importance. Keywords: idiopathic macular hole, vitrectomy, microperimetry, optical coherence tomography.

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