Effect of Triamcinolone Acetonide on Vascular Endothelial Growth Factor and Occludin Levels in Branch Retinal Vein Occlusion

2009 ◽  
Vol 147 (5) ◽  
pp. 838-846.e2 ◽  
Author(s):  
Ian L. McAllister ◽  
Sarojini Vijayasekaran ◽  
Simon D. Chen ◽  
Dao-Yi Yu
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Triamcinolone Acetonide ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Vascular Endothelial ◽  
Vein Occlusion ◽  
Endothelial Growth Factor

Change of cytokines after intravitreal ranibizumab in patients with recurrent branch retinal vein occlusion and macular edema

2019 ◽  
pp. 112067211988505 ◽  
Author(s):  
Hidetaka Noma ◽  
Kanako Yasuda ◽  
Masahiko Shimura
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Branch Retinal Vein Occlusion ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Intravitreal Ranibizumab ◽  
Vein Occlusion ◽  
Endothelial Growth Factor

Purpose: To investigate the relations of vascular endothelial growth factor, growth factors, soluble vascular endothelial growth factor receptors, and inflammatory factors to recurrence of macular edema after anti-vascular endothelial growth factor therapy in patients with branch retinal vein occlusion. Methods: This study retrospectively investigated 17 patients with branch retinal vein occlusion who received intravitreal ranibizumab injection three times within 6 months for recurrent macular edema. Aqueous humor samples were obtained from these patients at every recurrence. Levels of soluble vascular endothelial growth factor receptor-1, soluble vascular endothelial growth factor receptor-2, vascular endothelial growth factor, placental growth factor, platelet-derived growth factor-AA, soluble intercellular adhesion molecule-1, monocyte chemoattractant protein-1, interleukin-6, interleukin-8, interleukin-12(p70), and interleukin-13 were measured by the suspension array method. Aqueous flare values were measured with a laser flare meter and central macular thickness was determined by optical coherence tomography. Results: Mean best-corrected visual acuity and central macular thickness improved significantly over time after intravitreal ranibizumab injection, but the aqueous flare value at recurrence after intravitreal ranibizumab injection showed no significant change compared with baseline. Aqueous humor levels of soluble vascular endothelial growth factor receptor-1, soluble vascular endothelial growth factor receptor-2, vascular endothelial growth factor, platelet-derived growth factor-AA, monocyte chemoattractant protein-1, and interleukin-8 decreased significantly over time after intravitreal ranibizumab injection. However, there were no significant changes of the other five factors/cytokines (placental growth factor, soluble intercellular adhesion molecule-1, interleukin-6, interleukin-12, and interleukin-13) at recurrence after intravitreal ranibizumab injection compared with baseline. Conclusion: These findings suggest that persistent inflammation may influence the recurrence of macular edema in branch retinal vein occlusion patients, and that adding steroid therapy might be an effective strategy for preventing recurrence.

scholarly journals Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression

2019 ◽  
Author(s):  
Pan Long ◽  
Weiming Ya ◽  
Mengshan He ◽  
Qianli Zhang ◽  
Zhe Wang ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Retinal Vein Occlusion ◽  
Rat Model ◽  
Branch Retinal Vein Occlusion ◽  
Hydrogen Gas ◽  
Retinal Function ◽  
Vascular Endothelial ◽  
Vein Occlusion ◽  
Endothelial Growth Factor

Abstract Background: Oxidative stress (OS) is an essential factor in the pathogenesis of branch retinal vein occlusion (BRVO). Lines of studies have demonstrated the role of hydrogen gas in the regulation of OS. This study was designed to evaluate the effect of hydrogen gas on BRVO rat model which was established by modified laser photocoagulation method. Methods: 24 BRVO rats were randomly divided into two groups: hydrogen gas (H) group (42% H2, 21% O2, 37% N2) and model (M) group (21% O2, 79% N2). Rats in H group were inhaled with hydrogen gas for 8 hours every day continued to 30 d post-occlusion. 12 age-matched healthy rats were served as control (C) group. Retinal function and morphology were detected at 1, 7, 14 and 30 d post-occlusion. Furthermore, the expression of vascular endothelial growth factor (VEGF-α) was detected by immunofluorescent staining. Results: Full-field Electroretinography (FfERG) revealed that the amplitude of the d3.0 (dark-adaptation 3.0 response) b wave and OPs2 (oscillatory potentials) wave achieved quick recovery at 7 d post-occlusion in H group compared with M group (p<0.05; p<0.05). Retinal edema, especially in outer nuclear layer (ONL) at 1 d and 3 d post-occlusion in H group was slighter than M group (p<0.05). The reopen time of occlusive retinal vessel in H group was 2.235 ± 1.128 d, which was sooner than that in M group 4.234±2.236 d (p<0.05). Moreover, the flow velocity of ear vein blood was increased in H group compared with that in M group (p<0.05). The expression of VEGF-α in H group was dramatically decreasing compared with M group at 1 d, 7 d and 14 d post-occlusion (p<0.05), while there was no significant difference at 30 d post-occlusion (p>0.05). Conclusions: Our findings demonstrate that inhalation of hydrogen gas could alleviate retina edema, shorten reopen time and improve retinal function via decreasing VEGF-α expression. Key words: Hydrogen gas; branch retinal vein occlusion; electroretinography; vascular endothelial growth factor

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