Combining Asian and American Pedagogy to Improve Clinical Psychopharmacology Practice

2021 ◽  
pp. 102886
Author(s):  
Andrew T. Olagunju ◽  
Matthew Macaluso ◽  
Ira D. Glick
Keyword(s):  
Clinical Psychopharmacology

Modulation of ion channels in clinical psychopharmacology: adults and younger people

2010 ◽  
Vol 3 (3) ◽  
pp. 397-416 ◽  
Author(s):  
Lindsey I Sinclair ◽  
Peter T Dineen ◽  
Andrea L Malizia
Keyword(s):  
Ion Channels ◽  
Clinical Psychopharmacology

scholarly journals Repeated Dosing of Ketamine in the Forced Swim Test: Are Multiple Shots Better Than One?

2021 ◽  
Vol 12 ◽  
Author(s):  
Ridge G. Weston ◽  
Paul J. Fitzgerald ◽  
Brendon O. Watson
Keyword(s):  
Human Subjects ◽  
Forced Swim Test ◽  
Large Fraction ◽  
Clinical Psychopharmacology ◽  
Causative Factor ◽  
Rapid Onset ◽  
Swim Test ◽  
Forced Swim ◽  
Behavioral Studies ◽  
Repeated Dosing

The anesthetic drug ketamine has been successfully repurposed as an antidepressant in human subjects. This represents a breakthrough for clinical psychopharmacology, because unlike monoaminergic antidepressants, ketamine has rapid onset, including in Major Depressive Disorder (MDD) that is resistant to conventional pharmacotherapy. This rapid therapeutic onset suggests a unique mechanism of action, which continues to be investigated in reverse translational studies in rodents. A large fraction of rodent and human studies of ketamine have focused on the effects of only a single administration of ketamine, which presents a problem because MDD is typically a persistent illness that may require ongoing treatment with this drug to prevent relapse. Here we review behavioral studies in rodents that used repeated dosing of ketamine in the forced swim test (FST), with an eye toward eventual mechanistic studies. A subset of these studies carried out additional experiments with only a single injection of ketamine for comparison, and several studies used chronic psychosocial stress, where stress is a known causative factor in some cases of MDD. We find that repeated ketamine can in some cases paradoxically produce increases in immobility in the FST, especially at high doses such as 50 or 100 mg/kg. Several studies however provide evidence that repeated dosing is more effective than a single dose at decreasing immobility, including behavioral effects that last longer. Collectively, this growing literature suggests that repeated dosing of ketamine has prominent depression-related effects in rodents, and further investigation may help optimize the use of this drug in humans experiencing MDD.

Basic and Clinical Psychopharmacology of Nicotine

1991 ◽  
Vol 12 (4) ◽  
pp. 681-699
Author(s):  
Jacques Le Houezec ◽  
Neal L. Benowitz
Keyword(s):  
Clinical Psychopharmacology
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