Severe Cutaneous Reaction and Fever Due to Adalimumab

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Isabel Rodríguez-Nevado ◽  
Remedios Pérez-Calderón ◽  
Silvia Sánchez-Vega ◽  
Inmaculada Pérez-Rangel
2001 ◽  
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The Lancet ◽  
1998 ◽  
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Matías Mayor ◽  
Mariano Casado

2009 ◽  
Vol 48 (8) ◽  
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2014 ◽  
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2009 ◽  
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ABSTRACT In a male patient with rhinocerebral invasive aspergillosis, prolonged high-dosage oral administration of voriconazole led to hepatotoxicity combined with a severe cutaneous reaction while intravenous administration in the same patient did not. High concentrations in the portal blood precipitate liver enzyme abnormalities, and therefore, oral administration of voriconazole may have a hepatotoxicity profile different from that of intravenous (i.v.) administration. Intravenously administered voriconazole might still be an option after oral-voriconazole-induced toxicity has resolved.


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