Intravenous Voriconazole after Toxic Oral Administration
2009 ◽
Vol 54
(6)
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pp. 2741-2742
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Keyword(s):
ABSTRACT In a male patient with rhinocerebral invasive aspergillosis, prolonged high-dosage oral administration of voriconazole led to hepatotoxicity combined with a severe cutaneous reaction while intravenous administration in the same patient did not. High concentrations in the portal blood precipitate liver enzyme abnormalities, and therefore, oral administration of voriconazole may have a hepatotoxicity profile different from that of intravenous (i.v.) administration. Intravenously administered voriconazole might still be an option after oral-voriconazole-induced toxicity has resolved.
2008 ◽
Vol 11
(1)
◽
pp. 88
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2004 ◽
Vol 90
(5)
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pp. 1011-1015
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2011 ◽
Vol 6
(3)
◽
pp. 1934578X1100600
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Keyword(s):
2019 ◽
Vol 20
(21)
◽
pp. 5473
◽
1992 ◽
Vol 46
(2)
◽
pp. 452-454
Keyword(s):