Effects of immunization against bone morphogenetic protein-15 and growth differentiation factor-9 on ovarian function in mares

2018 ◽  
Vol 192 ◽  
pp. 69-77 ◽  
Author(s):  
Kelli A. Davis ◽  
Kristin M. Klohonatz ◽  
Darcy S.O. Mora ◽  
Hannah M. Twenter ◽  
Peter E. Graham ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Ovarian Function ◽  
Differentiation Factor ◽  
Morphogenetic Protein ◽  
Growth Differentiation Factor 9 ◽  
Bone Morphogenetic Protein 15

scholarly journals Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle

Reproduction ◽  
2009 ◽  
Vol 138 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Jennifer L Juengel ◽  
Norma L Hudson ◽  
Martin Berg ◽  
Keith Hamel ◽  
Peter Smith ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Ovarian Function ◽  
Follicular Development ◽  
Active Immunization ◽  
Ovulation Rate ◽  
Differentiation Factor ◽  
Morphogenetic Protein ◽  
Growth Differentiation Factor 9 ◽  
Bone Morphogenetic Protein 15 ◽  
Ovarian Follicular Development

Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are essential for ovarian follicular growth in sheep, whereas only GDF9 is essential in mice suggesting that the roles of these oocyte-derived growth factors differ among species. At present, however, there is only limited information on the action of BMP15 and GDF9 in other species. Thus, the aim of this experiment was to determine the effect of neutralizing GDF9 and/or BMP15in vivoon ovarian follicular development and ovulation rate in cattle through active immunization using the mature regions of the proteins or peptides from the N-terminal area of mature regions. Immunization with the BMP15 peptide, with or without GDF9 peptide, significantly altered (increased or decreased) ovulation rate. In some animals, there were no functional corpora lutea (CL), whereas in others up to four CL were observed. From morphometric examination of the ovaries, immunization with GDF9 and/or BMP15 reduced the level of ovarian follicular development as assessed by a reduced proportion of the ovarian section occupied by antral follicles. In addition, immunization against GDF9 and/or BMP15 peptides reduced follicular size to <25% of that in the controls. In conclusion, immunization against GDF9 and BMP15, alone or together, altered follicular development and ovulation rate in cattle. Thus, as has been observed in sheep, both GDF9 and BMP15 appear to be key regulators of normal follicular development and ovulation rate in cattle.

scholarly journals Synergistic Roles of Bone Morphogenetic Protein 15 and Growth Differentiation Factor 9 in Ovarian Function

2001 ◽  
Vol 15 (6) ◽  
pp. 854-866 ◽  
Author(s):  
Changning Yan ◽  
Pei Wang ◽  
Janet DeMayo ◽  
Francesco J. DeMayo ◽  
Julia A. Elvin ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Ovarian Function ◽  
Differentiation Factor ◽  
Morphogenetic Protein ◽  
Growth Differentiation Factor 9 ◽  
Bone Morphogenetic Protein 15
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