Studies on batch formulation of a kit for the preparation of the 99m Tc-Ubiquicidin (29-41): An infection imaging agent

2016 ◽  
Vol 107 ◽  
pp. 8-12 ◽  
Author(s):  
Chanda Arjun ◽  
Archana Mukherjee ◽  
Jyotsna Bhatt ◽  
Pradip Chaudhari ◽  
Krishna Mohan Repaka ◽  
...  
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pp. 169-175 ◽  
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S Penglis ◽  
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F.D.L Bartholomeusz

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Archana Mukherjee ◽  
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Molecules ◽  
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Author(s):  
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Yuhao Jiang ◽  
Qianqian Gan ◽  
Qing Ruan ◽  
Di Xiao ◽  
...  

In order to seek novel technetium-99m bacterial infection imaging agents, a ciprofloxacin xanthate (CPF2XT) was synthesized and radiolabeled with [99mTcN]2+ core to obtain the 99mTcN-CPF2XT complex, which exhibited high radiochemical purity, hydrophilicity, and good stability in vitro. The bacteria binding assay indicated that 99mTcN-CPF2XT had specificity to bacteria. A study of biodistribution in mice showed that 99mTcN-CPF2XT had a higher uptake in bacterial infection tissues than in turpentine-induced abscesses, indicating that it could distinguish bacterial infection from sterile inflammation. Compared to 99mTcN-CPFXDTC, the abscess/blood and abscess/muscle ratios of 99mTcN-CPF2XT were higher and the uptakes of 99mTcN-CPF2XT in the liver and lung were obviously decreased. The results suggested that 99mTcN-CPF2XT would be a potential bacterial infection imaging agent.


2010 ◽  
Vol 21 (12) ◽  
pp. 2282-2288 ◽  
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Kalme Sachin ◽  
Eun-Mi Kim ◽  
Su-Jin Cheong ◽  
Hwan-Jeong Jeong ◽  
Seok Tae Lim ◽  
...  

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Botshelo Mokaleng ◽  
Jacobus Venter ◽  
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...  

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pp. 652-657 ◽  
Author(s):  
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Zain Khurshid ◽  
Samina Roohi

2010 ◽  
Vol 287 (1) ◽  
pp. 21-25 ◽  
Author(s):  
S. F. Mirshojaei ◽  
M. Gandomkar ◽  
R. Najafi ◽  
S. E. Sadat Ebrahimi ◽  
M. H. Babaei ◽  
...  

1995 ◽  
Vol 16 (4) ◽  
pp. 238
Author(s):  
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A. V. Hall ◽  
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E. M. OʼShaughnessy ◽  
J. B. Bomanji ◽  
...  

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