scholarly journals The effect of a rehabilitation program after mesenchymal stromal cell transplantation for advanced osteonecrosis of the femoral head: a 10-year follow-up study

2022 ◽  
pp. 100179
Author(s):  
Tomoki Aoyama ◽  
Koji Goto ◽  
Ryosuke Ikeguchi ◽  
Manabu Nankaku ◽  
Katsuyuki Madoba ◽  
...  
Keyword(s):  
Femoral Head ◽  
Cell Transplantation ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Rehabilitation Program ◽  
Follow Up Study

scholarly journals Effects of human amnion–derived mesenchymal stromal cell transplantation in rats with radiation proctitis

Cytotherapy ◽  
2015 ◽  
Vol 17 (11) ◽  
pp. 1545-1559 ◽  
Author(s):  
Masayoshi Ono ◽  
Shunsuke Ohnishi ◽  
Minori Honda ◽  
Marin Ishikawa ◽  
Hidetaka Hosono ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Radiation Proctitis ◽  
Human Amnion

scholarly journals Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases

2019 ◽  
Vol 28 (7) ◽  
pp. 924-931
Author(s):  
Jingsong Wang ◽  
Karina T. Wright ◽  
Jade Perry ◽  
Bernhard Tins ◽  
Timothy Hopkins ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Knee Function ◽  
Cartilage Defects ◽  
Repair Site ◽  
Cell Implantation ◽  
Autologous Chondrocyte

Autologous chondrocyte implantation (ACI) has been used to treat cartilage defects for >20 years, with promising clinical outcomes. Here, we report two first-in-man cases (patient A and B) treated with combined autologous chondrocyte and bone marrow mesenchymal stromal cell implantation (CACAMI), with 8-year follow up. Two patients with International Cartilage Repair Society (ICRS) grade III–IV cartilage lesions underwent a co-implantation of autologous chondrocytes and bone marrow-derived mesenchymal stromal cells (BM-MSCs) between February 2008 and October 2009. In brief, chondrocytes and BM-MSCs were separately isolated and culture-expanded in a good manufacturing practice laboratory for a period of 2–4 weeks. Cells were then implanted in combination into cartilage defects and patients were clinically evaluated preoperatively and postoperatively, using the self-reported Lysholm knee score and magnetic resonance imaging (MRI). Postoperative Lysholm scores were compared with the Oswestry risk of knee arthroplasty (ORKA) scores. Patient A also had a second-look arthroscopy, at which time a biopsy of the repair site was taken. Both patients demonstrated a significant long-term improvement in knee function, with postoperative Lysholm scores being consistently higher than ORKA predictions. The most recent Lysholm scores, 8 years after surgery were 100/100 (Patient A) and 88/100 (Patient B), where 100 represents a fully functioning knee joint. Bone marrow lesion (BML) volume was shown to decrease on postoperative MRIs in both patients. Cartilage defect area increased in patient A, but declined initially for patient B, slightly increasing again 2 years after treatment. The repair site biopsy taken from patient A at 14 months postoperatively, demonstrated a thin layer of fibrocartilage covering the treated defect site. The use of a combination of cultured autologous chondrocytes and BM-MSCs appears to confer long-term benefit in this two-patient case study. Improvements in knee function perhaps relate to the observed reduction in the size of the BML.

scholarly journals Combination of the multipotent mesenchymal stromal cell transplantation with administration of temozolomide increases survival of rats with experimental glioblastoma

2015 ◽  
Vol 12 (2) ◽  
pp. 2828-2834 ◽  
Author(s):  
IGOR BRYUKHOVETSKIY ◽  
ANDREI BRYUKHOVETSKY ◽  
YURI KHOTIMCHENKO ◽  
POLINA MISCHENKO ◽  
ELENA TOLOK ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Multipotent Mesenchymal Stromal Cell

Bone marrow–mesenchymal stromal cell infusion in patients with chronic kidney disease: A safety study with 18 months of follow-up

Cytotherapy ◽  
2018 ◽  
Vol 20 (5) ◽  
pp. 660-669 ◽  
Author(s):  
Atieh Makhlough ◽  
Soroosh Shekarchian ◽  
Reza Moghadasali ◽  
Behzad Einollahi ◽  
Mona Dastgheib ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Bone Marrow ◽  
Kidney Disease ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Safety Study
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