Topical Tranexamic Acid May Improve Early Functional Outcomes of Primary Total Knee Arthroplasty

2016 ◽  
Vol 31 (7) ◽  
pp. 1449-1452 ◽  
Author(s):  
Laura Serrano Mateo ◽  
Kaveh Goudarz Mehdikhani ◽  
Libertad Cáceres ◽  
Yuo-yu Lee ◽  
Alejandro Gonzalez Della Valle
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Functional Outcomes ◽  
Primary Total Knee Arthroplasty ◽  
Total Knee ◽  
Topical Tranexamic Acid ◽  
Primary Total Knee

scholarly journals Subgroup Analysis of Topical Tranexamic Acid in Total Knee Arthroplasty

2014 ◽  
Vol 4 (2) ◽  
pp. 37-41 ◽  
Author(s):  
John Tuttle, MD ◽  
Walter Anazonwu, BS ◽  
Lee Rubin, MD
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Primary Outcome ◽  
Primary Total Knee Arthroplasty ◽  
Essential Question ◽  
Total Knee ◽  
Topical Tranexamic Acid ◽  
Primary Total Knee ◽  
Historical Controls

Evidence continues to accumulate for the efficacy of tranexamic acid (TXA) use in primary total knee arthroplasty (TKA).   An essential question that remains is to determine which specific subgroups of patients undergoing TKA will benefit from TXA use and if surgeons should be more selective in its administration. We performed a retrospective cohort study involving 187 TKA patients who received intraarticular (“topical”) TXA, and compared these to 168 historical controls who did not receive TXA. These patients were then subdivided into groups based on gender, age, BMI, and preoperative hemoglobin for analysis. All patients, despite their demographics, saw an improvement in primary outcome measures without a detectable increase in complications.  Based on these data, there are no restrictions on the use of TXA. Obese patients, females, and those over 65 years of age undergoing total knee arthroplasty may benefit from TXA most consistently.

scholarly journals Effect of Topical Tranexamic Acid on Reducing Blood Loss in Primary Total Knee Arthroplasty in Southern Chinese Population

2018 ◽  
Vol 25 (1) ◽  
pp. 73-75 ◽  
Author(s):  
Kwok Pui Pui ◽  
Ho Ka Ki ◽  
Yang Isaac Bruce ◽  
Sha Wai Leung ◽  
Wong Hok Leung ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
Postoperative Blood Loss ◽  
Transfusion Rate ◽  
Total Knee ◽  
Topical Tranexamic Acid ◽  
Primary Total Knee

The objective of this study was to evaluate the efficacy of topical tranexamic acid (TA) on the postoperative blood loss and transfusion rate after primary total knee arthroplasty (TKA). Two hundred ninety-six patients (n = 296) undergoing TKA in Pok Oi Hospital were included in this study from July 2015 to September 2016. The topical TA group (n =154) showed a significant reduction in haemoglobin drop (2.76 g/dL vs. 3.62 g/dL, p < 0.001), haematocrit drop (0.0876 vs. 0.112, p < 0.001), transfusion rate (3.2% vs. 23.9%, p < 0.001), drain output (199 mL vs. 276 mL, p < 0.001) and length of stay (9 days vs. 11 days, p < 0.001) compared with those in the control group (n = 142). There was no thromboembolic complication associated with TA use. The results supported the use of topical TA to control postoperative blood loss after TKA.

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