Living-Donor Lung Transplantation After Bone Marrow Transplantation for Chediak-Higashi Syndrome

Transplantation of normal bone marrow to mice with the Chediak-Higashi syndrome (CHS) resulted in normal granulopoiesis and a reversal of their increased susceptibility to challenge with intravenous Candida albicans. These findings suggest that (1) the leukocyte defect in CHS can be reversed by marrow transplantation and (2) the mechanism for increased susceptibility to infection in these animals is due to a bone- marrow-derived cellular defect. Because of similarities between murine and human CHS, bone marrow transplantation might be considered as a mode of therapy in selected cases of the human disease.

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Natural Killer Cell Activity in a Patient with Chédiak-Higashi Syndrome Submitted to Bone Marrow Transplantation

Pediatric Hematology and Oncology ◽

10.3109/08880019509029591 ◽

1995 ◽

Vol 12 (4) ◽

pp. 399-402 ◽

Cited By ~ 3

Author(s):

Hilda R. Diamond ◽

Maria Helena F. O. Souza ◽

Maria Luiza M. Silva ◽

Daniel G. Tabak ◽

Sima Ferman ◽

...

Keyword(s):

Bone Marrow ◽

Bone Marrow Transplantation ◽

Natural Killer Cell ◽

Natural Killer ◽

Marrow Transplantation ◽

Natural Killer Cell Activity ◽

Killer Cell ◽

Cell Activity ◽

Killer Cell Activity ◽

Chediak Higashi Syndrome

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Chediak-Higashi syndrome: neurocognitive and behavioral data from infancy to adulthood after bone marrow transplantation

Neurocase ◽

10.1080/13554794.2020.1856384 ◽

2020 ◽

pp. 1-7

Author(s):

Aino Yliranta ◽

Jussi Mäkinen

Keyword(s):

Bone Marrow ◽

Bone Marrow Transplantation ◽

Marrow Transplantation ◽

Behavioral Data ◽

Chediak Higashi Syndrome

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Histomorphologic Changes in the Bronchiolitis Obliterans Lung: Cartilaginous Airway Basal Stem Cells and Submucosal Glands Change Similarly Following Both Lung Transplantation and Bone Marrow Transplantation

10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7587 ◽

2020 ◽

Author(s):

K.R. Parekh ◽

T.J. Lynch ◽

B. Ahlers ◽

C. Werlein ◽

A. Pai ◽

...

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Bone Marrow Transplantation ◽

Lung Transplantation ◽

Marrow Transplantation ◽

Bronchiolitis Obliterans ◽

Submucosal Glands

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Chediak-Higashi syndrome: reversal of increased susceptibility to infection by bone marrow transplantation

Blood ◽

10.1182/blood.v47.4.555.555 ◽

1976 ◽

Vol 47 (4) ◽

pp. 555-559 ◽

Cited By ~ 25

Author(s):

JA Kazmierowski ◽

RJ Elin ◽

HY Reynolds ◽

WA Durbin ◽

SM Wolff

Keyword(s):

Bone Marrow ◽

Candida Albicans ◽

Bone Marrow Transplantation ◽

Human Disease ◽

Marrow Transplantation ◽

Normal Bone Marrow ◽

Susceptibility To Infection ◽

Normal Bone ◽

Chediak Higashi Syndrome ◽

Increased Susceptibility

Abstract Transplantation of normal bone marrow to mice with the Chediak-Higashi syndrome (CHS) resulted in normal granulopoiesis and a reversal of their increased susceptibility to challenge with intravenous Candida albicans. These findings suggest that (1) the leukocyte defect in CHS can be reversed by marrow transplantation and (2) the mechanism for increased susceptibility to infection in these animals is due to a bone- marrow-derived cellular defect. Because of similarities between murine and human CHS, bone marrow transplantation might be considered as a mode of therapy in selected cases of the human disease.

Download Full-text