scholarly journals 167: Reduced Intensity Versus Full Myeloablative Stem Cell Transplant for Advanced Chronic Lymphocytic Leukemia

2008 ◽  
Vol 14 (2) ◽  
pp. 62
Author(s):  
E. Peres ◽  
J. Levine ◽  
K. Kato ◽  
O. Krijanovski ◽  
Y. Khaled ◽  
...  
Keyword(s):  
Stem Cell ◽  
Chronic Lymphocytic Leukemia ◽  
Stem Cell Transplant ◽  
Lymphocytic Leukemia ◽  
Cell Transplant ◽  
Reduced Intensity

scholarly journals Successful Treatment of Richter Transformation with Ibrutinib in a Patient with Chronic Lymphocytic Leukemia following Allogeneic Hematopoietic Stem Cell Transplant

2017 ◽  
Vol 10 (2) ◽  
pp. 534-541 ◽  
Author(s):  
Samip Master ◽  
Cheri Leary ◽  
Amol Takalkar ◽  
James Coltelingam ◽  
Richard Mansour ◽  
...  
Keyword(s):  
Stem Cell ◽  
Chronic Lymphocytic Leukemia ◽  
Stem Cell Transplant ◽  
Case Reports ◽  
Single Agent ◽  
Lymphocytic Leukemia ◽  
Cell Transplant ◽  
Hematopoietic Stem ◽  
Mixed Response ◽  
Multi Agent

Patients with chronic lymphocytic leukemia (CLL) who progress to Richter transformation (RT) have a poor prognosis. Multi-agent chemotherapy regimens do not have good response rates. There are few case reports on the use of ibrutinib in RT. Here, we present a patient who was heavily pretreated for CLL, including allogeneic stem cell transplant, and progressed to RT. She had a mixed response to multi-agent chemotherapy and was started on ibrutinib. She had a complete response for 16 months on single-agent ibrutinib with minimal toxicity.

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