Successful Treatment of Richter Transformation with Ibrutinib in a Patient with Chronic Lymphocytic Leukemia following Allogeneic Hematopoietic Stem Cell Transplant
Keyword(s):
Patients with chronic lymphocytic leukemia (CLL) who progress to Richter transformation (RT) have a poor prognosis. Multi-agent chemotherapy regimens do not have good response rates. There are few case reports on the use of ibrutinib in RT. Here, we present a patient who was heavily pretreated for CLL, including allogeneic stem cell transplant, and progressed to RT. She had a mixed response to multi-agent chemotherapy and was started on ibrutinib. She had a complete response for 16 months on single-agent ibrutinib with minimal toxicity.
2012 ◽
Vol 53
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pp. 1699-1705
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2009 ◽
Vol 15
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pp. 4759-4768
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2017 ◽
Vol 23
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pp. S267
2008 ◽
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pp. 62
2012 ◽
Vol 18
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pp. S132-S138
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