scholarly journals Cord Blood Transplantation from Unrelated Donors for Children with Acute Lymphoblastic Leukemia in Japan: The Impact of Methotrexate on Clinical Outcomes

2011 ◽  
Vol 17 (12) ◽  
pp. 1814-1821 ◽  
Author(s):  
Koji Kato ◽  
Ayami Yoshimi ◽  
Etsuro Ito ◽  
Kentaro Oki ◽  
Juinichi Hara ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Cord Blood ◽  
Clinical Outcomes ◽  
Lymphoblastic Leukemia ◽  
Cord Blood Transplantation ◽  
Blood Transplantation ◽  
Unrelated Donors ◽  
The Impact

scholarly journals Effects of Cryopreservation Duration on the Outcome of Single-Unit Cord Blood Transplantation

2018 ◽  
Vol 27 (3) ◽  
pp. 515-519 ◽  
Author(s):  
Tang-Her Jaing ◽  
Shih-Hsiang Chen ◽  
Yu-Chuan Wen ◽  
Tsung-Yen Chang ◽  
Ya-Chun Yang ◽  
...  
Keyword(s):  
Cord Blood ◽  
Clinical Outcomes ◽  
Progenitor Cell ◽  
Cell Function ◽  
Cord Blood Transplantation ◽  
Blood Transplantation ◽  
The Impact ◽  
Transplantation Outcomes ◽  
Neutrophil Engraftment

Cryopreservation is widely used in umbilical cord blood (UCB) banking, yet its impact on progenitor cell function remains largely unaddressed. It is unknown whether long-term cryopreservation affects UCB transplantation outcomes. Herein, we evaluated the impact of UCB age on clinical outcomes and investigated the effect of cryopreservation duration of UCB on hematopoietic potency in 91 patients receiving single cord blood transplantations. UCB cryopreservation duration was 0.7 to 13.4 y. The most common indication of transplant was thalassemia (48%). There was no significant association between cryopreservation duration and neutrophil engraftment probability ( P = 0.475). Cryopreservation duration did not affect the post-thaw viability and subsequent neutrophil engraftment rate. Therefore, UCB units can undergo cryopreservation for at least 8 y with no impact on clinical outcomes.

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