Serum amyloid A stimulates matrix-metalloproteinase-9 upregulation via formyl peptide receptor like-1-mediated signaling in human monocytic cells

2005 ◽  
Vol 330 (3) ◽  
pp. 989-998 ◽  
Author(s):  
Ha Young Lee ◽  
Mi-Kyoung Kim ◽  
Kyoung Sun Park ◽  
Yun Hee Bae ◽  
Jeanho Yun ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Serum Amyloid A ◽  
Matrix Metalloproteinase 9 ◽  
Serum Amyloid ◽  
Formyl Peptide Receptor ◽  
Monocytic Cells ◽  
Peptide Receptor ◽  
Amyloid A ◽  
Formyl Peptide ◽  
Metalloproteinase 9

Serum Amyloid A Induces Contrary Immune Responses via Formyl Peptide Receptor-Like 1 in Human Monocytes

2006 ◽  
Vol 70 (1) ◽  
pp. 241-248 ◽  
Author(s):  
Ha Young Lee ◽  
Mi-Kyoung Kim ◽  
Kyoung Sun Park ◽  
Eun Ha Shin ◽  
Seong Ho Jo ◽  
...  
Keyword(s):  
Immune Responses ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Formyl Peptide Receptor ◽  
Human Monocytes ◽  
Peptide Receptor ◽  
Amyloid A ◽  
Formyl Peptide

E-selectin, Interleukin 18, Serum Amyloid A, and Matrix Metalloproteinase 9 Are Associated with Clinical Response to Golimumab plus Methotrexate in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy

2009 ◽  
Vol 36 (7) ◽  
pp. 1371-1379 ◽  
Author(s):  
SUDHA VISVANATHAN ◽  
CARRIE WAGNER ◽  
JEANNIE ROJAS ◽  
JONATHAN KAY ◽  
BHASKAR DASGUPTA ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
Clinical Response ◽  
Serum Amyloid A ◽  
Matrix Metalloproteinase 9 ◽  
Serum Amyloid ◽  
Inflammatory Biomarkers ◽  
Interleukin 18 ◽  
Amyloid A ◽  
Metalloproteinase 9

Objective.To assess the effect of golimumab (human monoclonal antibody to tumor necrosis factor-α) plus methotrexate (MTX) on selected inflammatory biomarkers, and to determine if these effects predict clinical response in rheumatoid arthritis (RA).Methods.Sera from adults with active RA despite MTX therapy, who received subcutaneous injections of placebo + MTX (MTX alone, n = 34) or golimumab 50 or 100 mg every 2 or 4 weeks + MTX (n = 137), were analyzed for levels of C-reactive protein (CRP), serum amyloid A (SAA), interleukin 18 (IL-18), E-selectin, matrix metalloproteinase 9 (MMP-9), and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1).Results.Golimumab + MTX treatment significantly decreased serum CRP, SAA, IL-18, E-selectin, TIMP-1, and MMP-9 levels (median percent changes of −4.1% to −74.3% across treatment groups) versus MTX alone (−5.8% to 9.7%) when first measured at Week 4; decreases were sustained through Week 16. Larger magnitudes of decrease in all biomarkers were observed for clinical responders versus nonresponders. For golimumab + MTX, regression analyses including all biomarkers and select clinical measures showed that reductions in levels of several markers (SAA, E-selectin, MMP-9) as early as Week 4 correlated significantly with improvement in swollen joint count (SJC) at Week 16, as did reductions in E-selectin with improvement in tender joint count at Week 16. After accounting for the biomarkers, however, treatment group was no longer significant for SJC.Conclusion.Significant decreases in several inflammatory biomarkers were associated with golimumab + MTX therapy. Decreases in serum levels of SAA, E-selectin, and MMP-9 at Week 4 may be useful in predicting clinical response at Week 16.

scholarly journals Serum Amyloid A Induces CCL2 Production via Formyl Peptide Receptor-Like 1-Mediated Signaling in Human Monocytes

2008 ◽  
Vol 181 (6) ◽  
pp. 4332-4339 ◽  
Author(s):  
Ha Young Lee ◽  
Sang Doo Kim ◽  
Jae Woong Shim ◽  
Sun Young Lee ◽  
Hwahyung Lee ◽  
...  
Keyword(s):  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Formyl Peptide Receptor ◽  
Human Monocytes ◽  
Peptide Receptor ◽  
Amyloid A ◽  
Formyl Peptide ◽  
Ccl2 Production

scholarly journals Serum Amyloid A Binding to Formyl Peptide Receptor-Like 1 Induces Synovial Hyperplasia and Angiogenesis

2006 ◽  
Vol 177 (8) ◽  
pp. 5585-5594 ◽  
Author(s):  
Mi-Sook Lee ◽  
Seung-Ah Yoo ◽  
Chul-Soo Cho ◽  
Pann-Ghill Suh ◽  
Wan-Uk Kim ◽  
...  
Keyword(s):  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Formyl Peptide Receptor ◽  
Synovial Hyperplasia ◽  
Peptide Receptor ◽  
Amyloid A ◽  
Formyl Peptide
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