Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene

2007 ◽  
Vol 363 (4) ◽  
pp. 971-977 ◽  
Author(s):  
Eui-Soon Park ◽  
Seunga Choi ◽  
Jin-Man Kim ◽  
Yongsu Jeong ◽  
Joonho Choe ◽  
...  
Keyword(s):  
Embryonic Lethality ◽  
Targeted Disruption ◽  
Interacting Protein ◽  
Early Embryonic Lethality

scholarly journals Targeted disruption of the mouse phospholipase C β3 gene results in early embryonic lethality

FEBS Letters ◽  
1998 ◽  
Vol 441 (2) ◽  
pp. 261-265 ◽  
Author(s):  
Shu Wang ◽  
Samuel Gebre-Medhin ◽  
Christer Betsholtz ◽  
Peter Stålberg ◽  
Yinghua Zhou ◽  
...  
Keyword(s):  
Phospholipase C ◽  
Embryonic Lethality ◽  
Targeted Disruption ◽  
Early Embryonic Lethality

Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene

2003 ◽  
Vol 305 (2) ◽  
pp. 278-286 ◽  
Author(s):  
Hirotaka Imai ◽  
Fumi Hirao ◽  
Taro Sakamoto ◽  
Kanae Sekine ◽  
Yumi Mizukura ◽  
...  
Keyword(s):  
Embryonic Lethality ◽  
Targeted Disruption ◽  
Early Embryonic Lethality

scholarly journals Targeted disruption of Rab10 causes early embryonic lethality

2015 ◽  
Vol 6 (6) ◽  
pp. 463-467 ◽  
Author(s):  
Pingping Lv ◽  
Yi Sheng ◽  
Zhenao Zhao ◽  
Wei Zhao ◽  
Lusheng Gu ◽  
...  
Keyword(s):  
Embryonic Lethality ◽  
Targeted Disruption ◽  
Early Embryonic Lethality

scholarly journals Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 ◽  
Vol 94 (8) ◽  
pp. 3801-3804 ◽  
Author(s):  
K. Takeda ◽  
K. Noguchi ◽  
W. Shi ◽  
T. Tanaka ◽  
M. Matsumoto ◽  
...  
Keyword(s):  
Embryonic Lethality ◽  
Targeted Disruption ◽  
Early Embryonic Lethality

scholarly journals Telomere-Associated Protein TIN2 Is Essential for Early Embryonic Development through a Telomerase-Independent Pathway

2004 ◽  
Vol 24 (15) ◽  
pp. 6631-6634 ◽  
Author(s):  
Y. Jeffrey Chiang ◽  
Sahn-Ho Kim ◽  
Lino Tessarollo ◽  
Judith Campisi ◽  
Richard J. Hodes
Keyword(s):  
Embryonic Development ◽  
Telomere Length ◽  
Embryonic Lethality ◽  
Negative Regulator ◽  
Telomeric Dna ◽  
Interacting Protein ◽  
Telomere Elongation ◽  
Dna Repeat ◽  
Early Embryonic Lethality ◽  
Length Regulation

ABSTRACT TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethality. We further observed that the embryonic lethality of TIN2 mutant mice was not affected by inactivation of the telomerase reverse transcriptase gene, indicating that embryonic lethality is not the result of telomerase-dependent changes in telomere length or function. Our findings suggest that TIN2 has a role independent of telomere length regulation that is essential for embryonic development and cell viability.

scholarly journals Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp)

1997 ◽  
Vol 94 (11) ◽  
pp. 5531-5534 ◽  
Author(s):  
M. R. Bosl ◽  
K. Takaku ◽  
M. Oshima ◽  
S. Nishimura ◽  
M. M. Taketo
Keyword(s):  
Trna Gene ◽  
Embryonic Lethality ◽  
Targeted Disruption ◽  
Early Embryonic Lethality

scholarly journals Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression

2006 ◽  
Vol 15 (19) ◽  
pp. 2936-2944 ◽  
Author(s):  
D.R.H. de Bruijn ◽  
W.J.M. Peters ◽  
S.M. Chuva de Sousa Lopes ◽  
A.H.A. van Dijk ◽  
M.P. Willemse ◽  
...  
Keyword(s):  
Synovial Sarcoma ◽  
Embryonic Lethality ◽  
Targeted Disruption ◽  
Early Embryonic Lethality

scholarly journals Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

2000 ◽  
Vol 10 (8) ◽  
pp. 479-482 ◽  
Author(s):  
A. de Klein ◽  
M. Muijtjens ◽  
R. van Os ◽  
Y. Verhoeven ◽  
B. Smit ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Checkpoint ◽  
Embryonic Lethality ◽  
Targeted Disruption ◽  
Checkpoint Gene ◽  
Early Embryonic Lethality ◽  
Cycle Checkpoint
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