Clotrimazole inhibits the Wnt/β-catenin pathway by activating two eIF2α kinases: The heme-regulated translational inhibitor and the double-stranded RNA-induced protein kinase

2018 ◽  
Vol 506 (1) ◽  
pp. 183-188 ◽  
Author(s):  
Honami Yonezawa ◽  
Mami Ogawa ◽  
Sota Katayama ◽  
Yui Shimizu ◽  
Norikazu Omori ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Double Stranded Rna ◽  
Translational Inhibitor

scholarly journals Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

1995 ◽  
Vol 14 (24) ◽  
pp. 6095-6106 ◽  
Author(s):  
Y. L. Yang ◽  
L. F. Reis ◽  
J. Pavlovic ◽  
A. Aguzzi ◽  
R. Schäfer ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Double Stranded Rna ◽  
Dependent Protein

scholarly journals Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication

2000 ◽  
Vol 74 (13) ◽  
pp. 6203-6206 ◽  
Author(s):  
Michael Bergmann ◽  
Adolfo Garcia-Sastre ◽  
Elena Carnero ◽  
Hubert Pehamberger ◽  
Klaus Wolff ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Life Cycle ◽  
Protein Kinase ◽  
Gene Knockout ◽  
Ns1 Protein ◽  
Double Stranded Rna ◽  
Major Function ◽  
Ns1 Gene ◽  
Biological Relationship ◽  
Knockout Virus

ABSTRACT The availability of an influenza virus NS1 gene knockout virus (delNS1 virus) allowed us to establish the significance of the biological relationship between the influenza virus NS1 protein and double-stranded-RNA-activated protein kinase (PKR) in the life cycle and pathogenicity of influenza virus. Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response.

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