scholarly journals Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: Treprostinil is a potent DP1 and EP2 agonist

2012 ◽  
Vol 84 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Brendan J. Whittle ◽  
Adam M. Silverstein ◽  
David M. Mottola ◽  
Lucie H. Clapp
Keyword(s):  
Prostanoid Receptors ◽  
Prostacyclin Receptor

scholarly journals Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets

1994 ◽  
Vol 266 (6) ◽  
pp. C1684-C1691 ◽  
Author(s):  
M. Berg ◽  
S. Offermanns ◽  
R. Seifert ◽  
G. Schultz
Keyword(s):  
Calcium Concentration ◽  
Cytosolic Calcium ◽  
Human Platelets ◽  
Cellular Effects ◽  
Prostacyclin Receptor ◽  
Serotonin Secretion ◽  
Peptide Moiety ◽  
Lipid Moiety ◽  
Molecular Masses ◽  
Aggregation Of Platelets

Lipopeptide analogues of the NH2-terminus of bacterial lipoprotein are known to induce activation of macrophages, neutrophils, and lymphocytes. We studied the effect of the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl-( S)-seryl-(S)-lysyl-(S)-lysyl-(S)-lysyl-(S)-lysine [Pam3CysSer(Lys)4] on several functions of human platelets. Pam3CysSer(Lys)4 led to the aggregation of platelets and induced the secretion of serotonin with an effectiveness similar to thrombin. These cellular effects of Pam3CysSer(Lys)4 were concentration dependent, being half maximal at 2-3 microM and maximal at 10-30 microM. Another lipopeptide also induced platelet aggregation and serotonin secretion but was less potent and less effective than Pam3CysSer(Lys)4. The lipid moiety and the peptide moiety of Pam3CysSer(Lys)4 alone were without any effect. Lipopeptides also stimulated tyrosine phosphorylation of several proteins with molecular masses similar to those found to be tyrosine phosphorylated in response to thrombin, and Pam3CysSer(Lys)4 led to an increase in the cytosolic calcium concentration. All studied responses of platelets to lipopeptides were inhibited by the prostacyclin receptor agonist cicaprost. Taken together, our data show that lipopeptides are effective activators of human platelets and that this activation is susceptible to the action of physiological platelet inhibitors.

scholarly journals Identification of the prostacyclin receptor by radiation inactivation.

1984 ◽  
Vol 259 (20) ◽  
pp. 12431-12436
Author(s):  
P J Leigh ◽  
W A Cramp ◽  
J MacDermot
Keyword(s):  
Radiation Inactivation ◽  
Prostacyclin Receptor

scholarly journals Characterization of prostanoid receptors mediating contraction of the gastric fundus and ileum: studies using mice deficient in prostanoid receptors

2000 ◽  
Vol 131 (4) ◽  
pp. 745-755 ◽  
Author(s):  
Yuji Okada ◽  
Akiyoshi Hara ◽  
Hong Ma ◽  
Chun-Yang Xiao ◽  
Osamu Takahata ◽  
...  
Keyword(s):  
Gastric Fundus ◽  
Prostanoid Receptors

scholarly journals Prostanoid receptors in human uterine myocytes: the effect of reproductive state and stretch

2005 ◽  
Vol 11 (12) ◽  
pp. 859-864 ◽  
Author(s):  
S.R. Sooranna ◽  
P. Grigsby ◽  
L. Myatt ◽  
P.R. Bennett ◽  
M.R. Johnson
Keyword(s):  
Reproductive State ◽  
Prostanoid Receptors

scholarly journals Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs

2007 ◽  
Vol 8 (1) ◽  
Author(s):  
Ralph T Schermuly ◽  
Soni S Pullamsetti ◽  
Susanne C Breitenbach ◽  
Norbert Weissmann ◽  
Hossein A Ghofrani ◽  
...  
Keyword(s):  
Prostacyclin Receptor

Prostacyclin Receptor-dependent Modulation of Pulmonary Vascular Remodeling

2001 ◽  
Vol 164 (2) ◽  
pp. 314-318 ◽  
Author(s):  
YASUSHI HOSHIKAWA ◽  
NORBERT F. VOELKEL ◽  
TRACY L. GESELL ◽  
MARK D. MOORE ◽  
KENNETH G. MORRIS ◽  
...  
Keyword(s):  
Vascular Remodeling ◽  
Pulmonary Vascular Remodeling ◽  
Prostacyclin Receptor

scholarly journals Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery

1995 ◽  
Vol 116 (1) ◽  
pp. 1692-1696 ◽  
Author(s):  
G.S. Baxter ◽  
J.K. Clayton ◽  
R.A. Coleman ◽  
K. Marshall ◽  
R. Sangha ◽  
...  
Keyword(s):  
Uterine Artery ◽  
Prostanoid Receptors

Characterization of contractile prostanoid receptors on human airway smooth muscle

1989 ◽  
Vol 165 (2-3) ◽  
pp. 215-222 ◽  
Author(s):  
Carol L. Armour ◽  
Peter R.A. Johnson ◽  
Maree L. Alfredson ◽  
Judith L. Black
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Human Airway Smooth Muscle ◽  
Prostanoid Receptors ◽  
Human Airway

scholarly journals Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP)

2012 ◽  
Vol 1823 (10) ◽  
pp. 1998-2012 ◽  
Author(s):  
Helen M. Reid ◽  
Elizebeth C. Turner ◽  
Eamon P. Mulvaney ◽  
Paula B. Hyland ◽  
Caitriona McLean ◽  
...  
Keyword(s):  
Family Member ◽  
Prostacyclin Receptor ◽  
Pdz Protein
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