APN1125: A clinical stage α7 nicotinic acetylcholine receptor partial agonist

Biochemical Pharmacology ◽

10.1016/j.bcp.2015.08.042 ◽

2015 ◽

Vol 97 (4) ◽

pp. 636 ◽

Author(s):

Gerald Koelsch ◽

Michael J. Detke ◽

Karen E. Stevens ◽

Leonard T. Meltzer ◽

Alvin V. Terry ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Clinical Stage ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors

Neuropharmacology ◽

10.1016/j.neuropharm.2011.10.024 ◽

2012 ◽

Vol 62 (2) ◽

pp. 1099-1110 ◽

Author(s):

Jos Prickaerts ◽

Nick P. van Goethem ◽

Richard Chesworth ◽

Gideon Shapiro ◽

Frank G. Boess ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Partial Agonist ◽

Memory Performance ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Α7 Nicotinic Acetylcholine Receptors

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(R)-3‘-(3-Methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3,5‘-oxazolidin]-2‘-one, a Novel and Potent α7 Nicotinic Acetylcholine Receptor Partial Agonist Displays Cognitive Enhancing Properties

Journal of Medicinal Chemistry ◽

10.1021/jm060249c ◽

2006 ◽

Vol 49 (14) ◽

pp. 4374-4383 ◽

Author(s):

Ryo Tatsumi ◽

Masakazu Fujio ◽

Shin-ichi Takanashi ◽

Atsushi Numata ◽

Jiro Katayama ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents

European Journal of Pharmacology ◽

10.1016/j.ejphar.2017.04.024 ◽

2017 ◽

Vol 807 ◽

pp. 1-11 ◽

Author(s):

Rick L. Pieschl ◽

Regina Miller ◽

Kelli M. Jones ◽

Debra J. Post-Munson ◽

Ping Chen ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Receptor Occupancy ◽

Sensory Gating ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Sulfonium as a Surrogate for Ammonium: A New α7 Nicotinic Acetylcholine Receptor Partial Agonist with Desensitizing Activity

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00875 ◽

2017 ◽

Vol 60 (18) ◽

pp. 7928-7934 ◽

Author(s):

Marta Quadri ◽

Clare Stokes ◽

Alican Gulsevin ◽

Ashley C. J. Felts ◽

Khalil A. Abboud ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Molecular dissection of tropisetron, an α7 nicotinic acetylcholine receptor-selective partial agonist

Neuroscience Letters ◽

10.1016/j.neulet.2004.12.025 ◽

2005 ◽

Vol 378 (3) ◽

pp. 140-144 ◽

Author(s):

Roger L. Papke ◽

Hillary C. Schiff ◽

Brian A. Jack ◽

Nicole A. Horenstein

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Molecular Dissection ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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Efficacy of Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation: A Randomized Controlled Trial

Yearbook of Pulmonary Disease ◽

10.1016/s8756-3452(08)70598-x ◽

2008 ◽

Vol 2008 ◽

pp. 109-110

Author(s):

L.T. Tanoue

Keyword(s):

Randomized Controlled Trial ◽

Smoking Cessation ◽

Sustained Release ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Controlled Trial ◽

Nicotinic Acetylcholine ◽

Randomized Controlled

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Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation: A Randomized Controlled Trial

Yearbook of Medicine ◽

10.1016/s0084-3873(08)70096-8 ◽

2007 ◽

Vol 2007 ◽

pp. 143-145

Author(s):

N.H. Hanna

Keyword(s):

Randomized Controlled Trial ◽

Smoking Cessation ◽

Sustained Release ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Controlled Trial ◽

Nicotinic Acetylcholine ◽

Randomized Controlled

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Activation of α7 nicotinic acetylcholine receptor alleviates cerebral cortical neuron injury induced by oxygen-glucose deprivation

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2015.00472 ◽

2015 ◽

Vol 36 (5) ◽

pp. 472

Author(s):

Ru-juan XIN ◽

Ting ZHAO ◽

Min NI ◽

Dong-jie LI ◽

Fu-ming SHEN

Keyword(s):

Cortical Neuron ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Glucose Deprivation ◽

Oxygen Glucose Deprivation ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Cerebral Cortical Neuron ◽

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Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113189 ◽

2021 ◽

Vol 214 ◽

pp. 113189

Author(s):

István Ledneczki ◽

Pál Tapolcsányi ◽

Eszter Gábor ◽

András Visegrády ◽

Márton Vass ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Scaffold Hopping ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

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Retracted : Role of α7‐nicotinic acetylcholine receptor in human non‐small cell lung cancer proliferation

Cell Proliferation ◽

10.1111/j.1365-2184.2008.00566.x ◽

2008 ◽

Vol 41 (6) ◽

pp. 936-959 ◽

Author(s):

L. Paleari ◽

A. Catassi ◽

M. Ciarlo ◽

Z. Cavalieri ◽

C. Bruzzo ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Small Cell Lung ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Cancer Proliferation ◽

Nicotinic Acetylcholine

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