Extracellular matrix production by adipose-derived stem cells: Implications for heart valve tissue engineering

Biomaterials ◽  
2011 ◽  
Vol 32 (1) ◽  
pp. 119-127 ◽  
Author(s):  
Francesca Colazzo ◽  
Padmini Sarathchandra ◽  
Ryszard T. Smolenski ◽  
Adrian H. Chester ◽  
Yuan-Tsan Tseng ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Extracellular Matrix ◽  
Heart Valve ◽  
Adipose Derived Stem Cells ◽  
Valve Tissue ◽  
Extracellular Matrix Production ◽  
Heart Valve Tissue ◽  
Matrix Production ◽  
Heart Valve Tissue Engineering

scholarly journals Human Mesenchymal Stem Cells Reendothelialize Porcine Heart Valve Scaffolds: Novel Perspectives in Heart Valve Tissue Engineering

2015 ◽  
Vol 4 (1) ◽  
pp. 288-297 ◽  
Author(s):  
Paola Lanuti ◽  
Francesco Serafini ◽  
Laura Pierdomenico ◽  
Pasquale Simeone ◽  
Giuseppina Bologna ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Heart Valve ◽  
Human Mesenchymal Stem Cells ◽  
Porcine Heart ◽  
Valve Tissue ◽  
Heart Valve Tissue ◽  
Heart Valve Tissue Engineering

The Potential of Prolonged Tissue Culture to Reduce Stress Generation and Retraction in Engineered Heart Valve Tissues

2011 ◽  
Author(s):  
Marijke A. A. van Vlimmeren ◽  
Anita Driessen-Mol ◽  
Cees W. J. Oomens ◽  
Frank P. T. Baaijens
Keyword(s):  
Heart Valve ◽  
Stress Generation ◽  
Tissue Formation ◽  
Scaffold Material ◽  
Traction Forces ◽  
Valve Tissue ◽  
Extracellular Matrix Production ◽  
Heart Valve Tissue ◽  
Matrix Production ◽  
Heart Valve Tissue Engineering

Heart valve tissue engineering (TE) relies on extracellular matrix production by cells seeded into a degrading scaffold material. Valves are cultured constraint with the leaflets attached to each other for 4 weeks [1]. The seeded cells naturally exert traction forces to their surroundings and due to an imbalance between scaffold, tissue and these traction forces, stress is generated within the tissue, which is good for tissue formation and architecture. However, during culture it causes tissue compaction, resulting in leaflet flattening, and at time of implantation, the leaflets are separated and the generated stress causes retraction of the leaflets (fig 1). This retraction on its turn results in loss of functionality.

The Cellular and Extracellular Matrix Structure of Human Pericardium for Heart Valve Tissue Engineering

2012 ◽  
Vol 2012 (4) ◽  
pp. 38 ◽  
Author(s):  
David Schornik ◽  
Frantisek Straka ◽  
Jaroslav Masin Jaroslav Masin ◽  
Elena F Filova ◽  
Zuzana Burdikova ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Heart Valve ◽  
Matrix Structure ◽  
Valve Tissue ◽  
Heart Valve Tissue ◽  
Heart Valve Tissue Engineering ◽  
Human Pericardium

Scaffolds and Stem Cells for Patient-Tailored Aortic Heart Valve Tissue Engineering

2012 ◽  
Vol 2012 (4) ◽  
pp. 76 ◽  
Author(s):  
Dan Simionescu ◽  
Michael Jaeggli ◽  
Jun Liao ◽  
Agneta Simionescu
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Heart Valve ◽  
Valve Tissue ◽  
Aortic Heart Valve ◽  
Heart Valve Tissue ◽  
Heart Valve Tissue Engineering
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