Design, synthesis and antitumor activity evaluation of novel HDAC inhibitors with tetrahydrobenzothiazole as the skeleton

2021 ◽  
Vol 108 ◽  
pp. 104652
Author(s):  
Simin Sun ◽  
Wenwen Zhao ◽  
Yongliang Li ◽  
Ziwei Chi ◽  
Xixi Fang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Hdac Inhibitors ◽  
Design Synthesis ◽  
Activity Evaluation

Design, synthesis, and antitumor activity evaluation of steroidal oximes

2021 ◽  
pp. 116360
Author(s):  
Ana R. Gomes ◽  
Ana S. Pires ◽  
Ana M. Abrantes ◽  
Ana C. Gonçalves ◽  
Saul C. Costa ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Design Synthesis ◽  
Activity Evaluation

scholarly journals Design, Synthesis, and Preliminary Antitumor Activity Evaluation of Novel Alkaloid Derivatives

2020 ◽  
Vol 15 (2) ◽  
pp. 1934578X2090353
Author(s):  
Li-Jiao Wang ◽  
Zhi-Xing Cao ◽  
Li Guo
Keyword(s):  
Antitumor Activity ◽  
Scaffold Hopping ◽  
Antitumor Activities ◽  
Design Synthesis ◽  
Tetrazolium Bromide ◽  
Activity Evaluation ◽  
H460 Cells

A novel alkaloid scaffold was designed through scaffold-hopping strategy based on the active pyrazines alkaloid isolated previously. A total of 25 derivatives were synthesized based on this scaffold and evaluated for their antitumor activities. Among all these tested compounds, 9f exhibited most excellent antitumor activities toward H460 cells, TMD-8 cells, and MV4-11 cells in vitro by 3-(4, 5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetrazolium bromide assay with IC50 values of 29.8, 14.9, and 18.8 μM, respectively.

scholarly journals Design, Synthesis and Antitumor Activity Evaluation of 4-Aminoquinazoline Derivatives Containing Urea Moiety

2019 ◽  
Vol 39 (10) ◽  
pp. 2875
Author(s):  
Erdong Li, ◽  
Yaqi Meng, ◽  
Luye Zhang, ◽  
Yang Zhang, ◽  
Jikuan Wang, ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Design Synthesis ◽  
Activity Evaluation

Design, Synthesis, and Antitumor Activity Evaluation of Trifluoromethyl-Substituted Pyrimidine Derivatives Containing Urea Moiety

2021 ◽  
Vol 47 (6) ◽  
pp. 1301-1311
Author(s):  
Liu Limin ◽  
Wang Zhengjie ◽  
Liu Xiujuan ◽  
Gao Chao ◽  
Dai Honglin ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Activity Evaluation

Design, synthesis and antitumor activity evaluation of Chrysamide B derivatives

2021 ◽  
pp. 104828
Author(s):  
Longqing Zhu ◽  
Junfang Li ◽  
Xiaohong Fan ◽  
Xiaoling Hu ◽  
Jinhong Chen ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Design Synthesis ◽  
Activity Evaluation

scholarly journals Design, Synthesis and Antitumor Activity Evaluation Research of Novel 2,4,6-Substituted Pyrimidine Derivatives

2021 ◽  
Vol 41 (1) ◽  
pp. 310
Author(s):  
Yang Zhang ◽  
Luye Zhang ◽  
Jikuan Wang ◽  
Limin Liu ◽  
Tao Wang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Evaluation Research ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Activity Evaluation
Sign in / Sign up

Export Citation Format

Share Document