Evaluating the Efficacy of Recombinant Human Bone Morphogenic Protein-2 in the Treatment of Alveolar Cleft with Autologous Bone Grafting using Computer-Aided Engineering Techniques

This case report aims to describe in detail a complication associated with resorption of regenerated bone following implant placement and ridge augmentation using recombinant human bone morphogenic protein–2 (rhBMP-2) in combination with allograft and xenograft. Bilateral maxillary sinus and ridge augmentation procedures were completed using rhBMP-2 combined with allograft and xenograft. Five months later, significant bone augmentation was achieved, which allowed for the placement of 4 implants. Upon stage 2 surgery, significant dehiscence was noted in all implants. Treatment steps to address this complication included implant removal, guided bone regeneration with xenograft only, and placement of new implants followed by soft-tissue grafting. At the time of publication, this patient is status 1½ years post case completion with maintenance of therapy outcomes. Off-label use of rhBMP-2 has gained significant acceptance in implant dentistry. However, there is limited evidence regarding the bone maturation process when rhBMP-2 is combined with other biomaterials. More research may be needed regarding the timing and process of bone healing in the presence of rhBMP-2, in an effort to avoid surgical complications.

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Does Recombinant Human Bone Morphogenic Protein 2 Affect Perioperative Blood Loss after Lumbar and Thoracic Spinal Fusion?

Asian Spine Journal ◽

10.31616/asj.2018.12.5.880 ◽

2018 ◽

Vol 12 (5) ◽

pp. 880-886 ◽

Cited By ~ 1

Author(s):

Nathan Wanderman ◽

Bayard Carlson ◽

William Robinson ◽

Mohamad Bydon ◽

Michael Yaszemski ◽

...

Keyword(s):

Blood Loss ◽

Spinal Fusion ◽

Bone Morphogenic Protein ◽

Human Bone ◽

Perioperative Blood Loss ◽

Thoracic Spinal ◽

Bone Morphogenic Protein 2 ◽

Recombinant Human Bone

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3:51 Recombinant human bone morphogenic protein–2 for posterolateral spine fusion

The Spine Journal ◽

10.1016/s1529-9430(02)00319-4 ◽

2002 ◽

Vol 2 (5) ◽

pp. 72

Author(s):

Scott D. Boden ◽

James D. Kang ◽

Harvinder Sandhu ◽

John G. Heller

Keyword(s):

Spine Fusion ◽

Bone Morphogenic Protein ◽

Human Bone ◽

Posterolateral Spine Fusion ◽

Bone Morphogenic Protein 2 ◽

Recombinant Human Bone

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Recombinant human bone morphogenic protein-2 (Rhbmp-2) immobilization onto the surface of apatite-coated titanium significantly promotes osteoblast function and mineralization

Tissue Engineering and Regenerative Medicine ◽

10.1007/s13770-012-0335-7 ◽

2012 ◽

Vol 9 (4) ◽

pp. 216-223 ◽

Cited By ~ 3

Author(s):

Sung Eun Kim ◽

Young Pil Yun ◽

Dong Hun Suh ◽

Young Ran Kim ◽

Kyeongsoon Park ◽

...

Keyword(s):

Bone Morphogenic Protein ◽

Human Bone ◽

Osteoblast Function ◽

Bone Morphogenic Protein 2 ◽

Recombinant Human Bone

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Evaluation of Bone Volume after Secondary Bone Grafting in Unilateral Alveolar Cleft Using Computer-Aided Engineering

The Cleft Palate-Craniofacial Journal ◽

10.1597/13-045 ◽

2014 ◽

Vol 51 (6) ◽

pp. 665-668 ◽

Cited By ~ 18

Author(s):

Hayato Nagashima ◽

Yoshiaki Sakamoto ◽

Hisao Ogata ◽

Junpei Miyamoto ◽

Masaki Yazawa ◽

...

Keyword(s):

Cleft Palate ◽

Bone Graft ◽

Bone Grafting ◽

Three Dimensional ◽

Bone Grafts ◽

Bone Volume ◽

Computer Aided Engineering ◽

Alveolar Cleft ◽

Alveolar Bone Grafting ◽

Computer Aided

The purpose of this study was to evaluate the initial defect and the outcome of bone grafts for unilateral alveolar cleft. To determine the absorption of the bone graft in patients with unilateral cleft, computer-aided engineering (CAE) with multi-detector row computed tomography (MDCT) was used. MDCT scans of 29 patients were taken immediately preoperatively and at 1 month and 6 months postoperatively. The patients underwent bone grafting between 8 and 14 years of age using iliac crest bone grafts. Three-dimensional models were created in each period, and the defect at the alveolar cleft and volume of the bone graft were determined in each patient using CAE. Cleft volume and success of alveolar bone grafting were significantly correlated ( P < .01). Alveolar clefts with cleft palate required more bone volume than those without cleft palate ( P < .01), but the resorption rate did not significantly differ between alveolar clefts with and without cleft palate (0.48 ± 0.14 and 0.49 ± 0.18, respectively; P =.93). In conclusion, three-dimensional reconstruction of bone grafts using CAE based on MDCT provides a valuable objective assessment of graft volume.

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