In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones

2004 ◽  
Vol 12 (18) ◽  
pp. 4885-4893 ◽  
Author(s):  
Gabriela Aguirre ◽  
Lucı́a Boiani ◽  
Hugo Cerecetto ◽  
Marcelo Fernández ◽  
Mercedes González ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Mechanism Of Action ◽  
Protozoan Parasite ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi

2004 ◽  
Vol 99 (2) ◽  
pp. 233-235 ◽  
Author(s):  
Patricia B Petray ◽  
María J Morilla ◽  
Ricardo S Corral ◽  
Eder L Romero
Keyword(s):  
Trypanosoma Cruzi ◽  
Protozoan Parasite ◽  
Vitro Activity ◽  
In Vitro Activity

scholarly journals Differential in vitro activity of the DNA topoisomerase inhibitor idarubicin against Trypanosoma rangeli and Trypanosoma cruzi

2012 ◽  
Vol 107 (7) ◽  
pp. 946-950 ◽  
Author(s):  
Momodou Jobe ◽  
Charles Anwuzia-Iwegbu ◽  
Ama Banful ◽  
Emma Bosier ◽  
Mubeen Iqbal ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Trypanosoma Rangeli ◽  
Dna Topoisomerase ◽  
Topoisomerase Inhibitor

Evaluation of the in vitro activity of ceragenins against Trichomonas vaginalis

2016 ◽  
Vol 61 (2) ◽  
Author(s):  
Zubeyde Akin Polat ◽  
Ali Cetin ◽  
Poul B. Savage
Keyword(s):  
Trichomonas Vaginalis ◽  
Protozoan Parasite ◽  
Vitro Activity ◽  
In Vitro Activity

AbstractTrichomonosis, caused by the protozoan parasite

scholarly journals Diphenyl Furans and Aza Analogs: Effects of Structural Modification on In Vitro Activity, DNA Binding, and Accumulation and Distribution in Trypanosomes

2007 ◽  
Vol 51 (8) ◽  
pp. 2801-2810 ◽  
Author(s):  
Amanda M. Mathis ◽  
Arlene S. Bridges ◽  
Mohamed A. Ismail ◽  
Arvind Kumar ◽  
Iris Francesconi ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Structural Modification ◽  
Human African Trypanosomiasis ◽  
Treatment Options ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Antitrypanosomal Activity ◽  
Specific Accumulation ◽  
High Concentrations

ABSTRACT Human African trypanosomiasis is a devastating disease with only a few treatment options, including pentamidine. Diamidine compounds such as pentamidine, DB75, and DB820 are potent antitrypanosomal compounds. Previous investigations have shown that diamidines accumulate to high concentrations in trypanosomes. However, the mechanism of action of this class of compounds remains unknown. A long-hypothesized mechanism of action has been binding to DNA and interference with DNA-associated enzymes. The fluorescent diamidines, DB75 and DB820, have been shown to localize not only in the DNA-containing nucleus and kinetoplast of trypanosomes but also to the acidocalcisomes. Here we investigate two series of analogs of DB75 and DB820 with various levels of in vitro antitrypanosomal activity to determine whether any correlation exists between trypanosome accumulation, distribution, and in vitro activity. Despite wide ranges of in vitro antitrypanosomal activity, all of the compounds investigated accumulated to millimolar concentrations in trypanosomes over a period of 8 h. Interestingly, some of the less potent compounds accumulated to concentrations much higher than those of more potent compounds. All of the compounds were localized to the DNA-containing nucleus and/or kinetoplast, and many were also found in the acidocalcisomes. Accumulation in the nucleus and kinetoplast should be important to the mechanism of action of these compounds. The acidocalcisomes may also play a role in the mechanism of action of these compounds. This investigation suggests that the extent of accumulation alone is not responsible for killing trypanosomes and that organelle-specific accumulation may not predict in vitro activity.

Manganese(II) complexes with N4-methyl-4-nitrobenzaldehyde, N4-methyl-4-nitroacetofenone, and N4-methyl-4-nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi

Polyhedron ◽  
2010 ◽  
Vol 29 (10) ◽  
pp. 2232-2238 ◽  
Author(s):  
Denise da Gama Jaén Batista ◽  
Patrícia Bernardino da Silva ◽  
Daniela R. Lachter ◽  
Renata S. Silva ◽  
Ricardo Q. Aucelio ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
In Vitro Activity

Aromatic guanyl hydrazones: Synthesis, structural studies and in vitro activity against Trypanosoma cruzi

1995 ◽  
Vol 5 (24) ◽  
pp. 3079-3084 ◽  
Author(s):  
J.C. Messeder ◽  
L.W. Tinoco ◽  
J.D. Figueroa-Villar ◽  
E.M. Souza ◽  
R. Santa Rita ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
Structural Studies ◽  
In Vitro Activity

1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi

2007 ◽  
Vol 15 (5) ◽  
pp. 2081-2091 ◽  
Author(s):  
Marinela Rodríguez-Ciria ◽  
Ana M. Sanz ◽  
María J.R. Yunta ◽  
Fernando Gómez-Contreras ◽  
Pilar Navarro ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
Dinuclear Complexes ◽  
In Vitro Activity

scholarly journals Trypanosoma cruzi: in vitro activity of Epoxy-α-Lap, a derivative of α-lapachone, on trypomastigote and amastigote forms

2009 ◽  
Vol 122 (2) ◽  
pp. 91-96 ◽  
Author(s):  
S.C. Bourguignon ◽  
H.C. Castro ◽  
D.O. Santos ◽  
C.R. Alves ◽  
V.F. Ferreira ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vitro Activity ◽  
In Vitro Activity
Sign in / Sign up

Export Citation Format

Share Document