Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV

2007 ◽  
Vol 15 (7) ◽  
pp. 2715-2735 ◽  
Author(s):  
Takashi Kondo ◽  
Isamu Sugimoto ◽  
Takahiro Nekado ◽  
Kenya Ochi ◽  
Tazumi Ohtani ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Design And Synthesis ◽  
Long Acting

Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

2005 ◽  
Vol 48 (15) ◽  
pp. 5025-5037 ◽  
Author(s):  
David J. Augeri ◽  
Jeffrey A. Robl ◽  
David A. Betebenner ◽  
David R. Magnin ◽  
Ashish Khanna ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Long Acting ◽  
Orally Active

Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration

2007 ◽  
Vol 15 (7) ◽  
pp. 2631-2650 ◽  
Author(s):  
Takashi Kondo ◽  
Takahiro Nekado ◽  
Isamu Sugimoto ◽  
Kenya Ochi ◽  
Shigeyuki Takai ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Design And Synthesis ◽  
Dipeptidyl Peptidase Iv Inhibitors

Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

2010 ◽  
Vol 20 (3) ◽  
pp. 1109-1113 ◽  
Author(s):  
Patrizio Mattei ◽  
Markus Boehringer ◽  
Patrick Di Giorgio ◽  
Holger Fischer ◽  
Michael Hennig ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Long Acting

Design and Synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as Dipeptidyl Peptidase IV Inhibitors

ChemMedChem ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. 1104-1116 ◽  
Author(s):  
Linrong Zhu ◽  
Yuanyuan Li ◽  
Ling Qiu ◽  
Mingbo Su ◽  
Xin Wang ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Design And Synthesis ◽  
Dipeptidyl Peptidase Iv Inhibitors

Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors

2008 ◽  
Vol 18 (7) ◽  
pp. 2362-2367 ◽  
Author(s):  
Michael B. Wallace ◽  
Jun Feng ◽  
Zhiyuan Zhang ◽  
Robert J. Skene ◽  
Lihong Shi ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Benzimidazole Derivatives ◽  
Design And Synthesis ◽  
Dipeptidyl Peptidase Iv Inhibitors

Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors

2009 ◽  
Vol 19 (7) ◽  
pp. 1908-1912 ◽  
Author(s):  
Ting-Yueh Tsai ◽  
Tsu Hsu ◽  
Chiung-Tong Chen ◽  
Jai-Hong Cheng ◽  
Mei-Chun Chiou ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Rational Design ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Design And Synthesis ◽  
Dipeptidyl Peptidase Iv Inhibitors

Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV

2011 ◽  
Vol 54 (2) ◽  
pp. 510-524 ◽  
Author(s):  
Zhiyuan Zhang ◽  
Michael B. Wallace ◽  
Jun Feng ◽  
Jeffrey A. Stafford ◽  
Robert J. Skene ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Design And Synthesis

K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent

2004 ◽  
Vol 486 (3) ◽  
pp. 335-342 ◽  
Author(s):  
Kotaro Takasaki ◽  
Miho Iwase ◽  
Takao Nakajima ◽  
Kimihisa Ueno ◽  
Yuji Nomoto ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Hypoglycemic Agent ◽  
Long Acting ◽  
Slow Binding Inhibitor

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

2011 ◽  
Vol 19 (1) ◽  
pp. 172-185 ◽  
Author(s):  
Yasufumi Miyamoto ◽  
Yoshihiro Banno ◽  
Tohru Yamashita ◽  
Tatsuhiko Fujimoto ◽  
Satoru Oi ◽  
...  
Keyword(s):  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Design And Synthesis
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