Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain

2010 ◽  
Vol 18 (22) ◽  
pp. 7816-7825 ◽  
Author(s):  
Marc J.C. Scanio ◽  
Lei Shi ◽  
Irene Drizin ◽  
Robert J. Gregg ◽  
Robert N. Atkinson ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sodium Channel ◽  
Biological Evaluation ◽  
Orally Bioavailable ◽  
Nav1.8 Sodium Channel

scholarly journals DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain

2017 ◽  
Vol 38 (5) ◽  
pp. 1124-1136 ◽  
Author(s):  
Yan Li ◽  
Robert Y. North ◽  
Laurence D. Rhines ◽  
Claudio Esteves Tatsui ◽  
Ganesh Rao ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sodium Channel ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated

Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2AReceptor Antagonists and Their Biological Evaluation

2017 ◽  
Vol 60 (2) ◽  
pp. 681-694 ◽  
Author(s):  
Sujay Basu ◽  
Dinesh A. Barawkar ◽  
Sachin Thorat ◽  
Yogesh D. Shejul ◽  
Meena Patel ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Orally Bioavailable

scholarly journals Rufinamide Attenuates Mechanical Allodynia in a Model of Neuropathic Pain in the Mouse and Stabilizes Voltage-gated Sodium Channel Inactivated State

2013 ◽  
Vol 118 (1) ◽  
pp. 160-172 ◽  
Author(s):  
Marc R. Suter ◽  
Guylène Kirschmann ◽  
Cedric J. Laedermann ◽  
Hugues Abriel ◽  
Isabelle Decosterd
Keyword(s):  
Neuropathic Pain ◽  
Sodium Channel ◽  
Mechanical Allodynia ◽  
Voltage Gated Sodium Channel ◽  
Voltage Gated
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