Synthesis and biological evaluation of pyrrolidine derivatives as novel and potent sodium channel blockers for the treatment of ischemic stroke

2013 ◽  
Vol 23 (14) ◽  
pp. 4230-4234 ◽  
Author(s):  
Maki Seki ◽  
Osamu Tsuruta ◽  
Ryo Tatsumi ◽  
Aki Soejima
Keyword(s):  
Ischemic Stroke ◽  
Sodium Channel ◽  
Biological Evaluation ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection

2016 ◽  
Vol 14 (36) ◽  
pp. 8457-8473 ◽  
Author(s):  
Satish Chandra Philkhana ◽  
Suneet Mehrotra ◽  
Thomas F. Murray ◽  
D. Srinivasa Reddy
Keyword(s):  
Total Synthesis ◽  
Sodium Channel ◽  
Biological Evaluation ◽  
Detailed Account ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
Channel Inhibition ◽  
Synthesis And Biological Evaluation

A detailed account on total synthesis, analogue synthesis, biological evaluation and SAR of palmyrolide A macrocycles towards sodium channel inhibition is reported.

2,4(5)-Diarylimidazoles: Synthesis and biological evaluation of a new class of sodium channel blockers against hNav1.2

2008 ◽  
Vol 18 (20) ◽  
pp. 5460-5462 ◽  
Author(s):  
Mirko Rivara ◽  
Aparna R. Baheti ◽  
Marco Fantini ◽  
Giuseppe Cocconcelli ◽  
Chiara Ghiron ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Biological Evaluation ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
New Class ◽  
Synthesis And Biological Evaluation

Reconsidering the role of selective sodium channel blockers in genetic generalized epilepsy

2021 ◽  
Author(s):  
Emanuele Cerulli Irelli ◽  
Alessandra Morano ◽  
Martina Fanella ◽  
Biagio Orlando ◽  
Enrico M Salamone ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
Generalized Epilepsy

ChemInform Abstract: Substituted Biaryl Pyrazoles as Sodium Channel Blockers.

ChemInform ◽  
2010 ◽  
Vol 41 (52) ◽  
pp. no-no
Author(s):  
Sriram Tyagarajan ◽  
et al. et al.
Keyword(s):  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers

scholarly journals Diphenytoin, riluzole and lidocaine: Three sodium channel blockers, with different mechanisms of action, decrease hippocampal epileptiform activity

2013 ◽  
Vol 73 ◽  
pp. 48-55 ◽  
Author(s):  
Lihong Diao ◽  
Jennifer L. Hellier ◽  
Jessica Uskert-Newsom ◽  
Philip A. Williams ◽  
Kevin J. Staley ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Epileptiform Activity ◽  
Mechanisms Of Action ◽  
Channel Blockers ◽  
Sodium Channel Blockers
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