nav1.8 sodium channel
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scholarly journals Functional up-regulation of Nav1.8 sodium channel on dorsal root ganglia neurons contributes to the induction of scorpion sting pain

2016 ◽  
Vol 48 (2) ◽  
pp. 132-144 ◽  
Author(s):  
Pin Ye ◽  
Liming Hua ◽  
Yunlu Jiao ◽  
Zhenwei Li ◽  
Shichao Qin ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Scorpion Sting ◽  
Dorsal Root Ganglia Neurons ◽  
Nav1.8 Sodium Channel

scholarly journals Dexmedetomidine inhibits Tetrodotoxin-resistant Nav1.8 sodium channel activity through Gi/o-dependent pathway in rat dorsal root ganglion neurons

2015 ◽  
Vol 8 (1) ◽  
pp. 15 ◽  
Author(s):  
Xi-Yao Gu ◽  
Ben-Long Liu ◽  
Kai-Kai Zang ◽  
Liu Yang ◽  
Hua Xu ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Sodium Channel ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Channel Activity ◽  
Ganglion Neurons ◽  
Nav1.8 Sodium Channel ◽  
Dependent Pathway

scholarly journals Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation

2014 ◽  
Vol 11 (1) ◽  
pp. 45 ◽  
Author(s):  
Mounir Belkouch ◽  
Marc-André Dansereau ◽  
Pascal Tétreault ◽  
Michael Biet ◽  
Nicolas Beaudet ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Peripheral Inflammation ◽  
Afferent Fibers ◽  
Nav1.8 Sodium Channel

scholarly journals The Chemokine CCL2 Increases Nav1.8 Sodium Channel Activity in Primary Sensory Neurons through a G  -Dependent Mechanism

2011 ◽  
Vol 31 (50) ◽  
pp. 18381-18390 ◽  
Author(s):  
M. Belkouch ◽  
M.-A. Dansereau ◽  
A. Reaux-Le Goazigo ◽  
J. Van Steenwinckel ◽  
N. Beaudet ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
Channel Activity ◽  
Nav1.8 Sodium Channel ◽  
Dependent Mechanism

scholarly journals The Selective Nav1.8 Sodium Channel Blocker A-803467 Affects Electrical Activity in Intracardiac Neurons, but not in Cardiomyocytes

2011 ◽  
Vol 100 (3) ◽  
pp. 421a-422a
Author(s):  
Marieke W. Veldkamp ◽  
Carol A. Remme ◽  
Brendon Scicluna ◽  
Cees A. Schumacher ◽  
Rianne Wolswinkel ◽  
...  
Keyword(s):  
Electrical Activity ◽  
Sodium Channel ◽  
Channel Blocker ◽  
Sodium Channel Blocker ◽  
Nav1.8 Sodium Channel ◽  
Intracardiac Neurons

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain

2010 ◽  
Vol 18 (22) ◽  
pp. 7816-7825 ◽  
Author(s):  
Marc J.C. Scanio ◽  
Lei Shi ◽  
Irene Drizin ◽  
Robert J. Gregg ◽  
Robert N. Atkinson ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sodium Channel ◽  
Biological Evaluation ◽  
Orally Bioavailable ◽  
Nav1.8 Sodium Channel

Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives

2010 ◽  
Vol 20 (22) ◽  
pp. 6812-6815 ◽  
Author(s):  
Michael E. Kort ◽  
Robert N. Atkinson ◽  
James B. Thomas ◽  
Irene Drizin ◽  
Matthew S. Johnson ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
Nicotinamide Derivatives ◽  
Nav1.8 Sodium Channel ◽  
Subtype Selective ◽  
Orally Active

A-887826 is a structurally novel, potent and voltage-dependent Nav1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats

2010 ◽  
Vol 59 (3) ◽  
pp. 201-207 ◽  
Author(s):  
Xu-Feng Zhang ◽  
Char-Chang Shieh ◽  
Mark L. Chapman ◽  
Mark A. Matulenko ◽  
Ahmed H. Hakeem ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Channel Blocker ◽  
Tactile Allodynia ◽  
Sodium Channel Blocker ◽  
Voltage Dependent ◽  
Nav1.8 Sodium Channel

Synthesis of PF-1247324, a NaV1.8 Sodium Channel Modulator

Synfacts ◽  
2010 ◽  
Vol 2010 (04) ◽  
pp. 0385-0385
Keyword(s):  
Sodium Channel ◽  
Nav1.8 Sodium Channel ◽  
Channel Modulator
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