Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: Solution and X-ray crystallographic studies

X Ray

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide—two heads are better than one?

10.1016/s0960-894x(03)00508-0 ◽

2003 ◽

Vol 13 (16) ◽

pp. 2759-2763 ◽

Cited By ~ 27

Author(s):

Angela Casini ◽

Francesco Abbate ◽

Andrea Scozzafava ◽

Claudiu T Supuran

Keyword(s):

Carbonic Anhydrase ◽

Crystallographic Structure ◽

X Ray ◽

Better Than

Carbonic anhydrase inhibitors: The X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors

10.1016/j.bmcl.2008.03.023 ◽

2008 ◽

Vol 18 (8) ◽

pp. 2669-2674 ◽

Cited By ~ 23

Author(s):

Anna Di Fiore ◽

Carlo Pedone ◽

Jochen Antel ◽

Harald Waldeck ◽

Andreas Witte ◽

...

Keyword(s):

Crystal Structure ◽

Carbonic Anhydrase ◽

Tight Binding ◽

X Ray ◽

Binding Inhibitors

Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride

10.1016/j.bmcl.2003.11.014 ◽

2004 ◽

Vol 14 (2) ◽

pp. 337-341 ◽

Cited By ~ 46

Author(s):

Francesco Abbate ◽

Anita Coetzee ◽

Angela Casini ◽

Samuele Ciattini ◽

Andrea Scozzafava ◽

...

Keyword(s):

Carbonic Anhydrase ◽

Antipsychotic Drug ◽

Crystallographic Structure ◽

X Ray

Carbonic Anhydrase Inhibitors: X-ray Crystallographic Structure of the Adduct of Human Isozyme II with the Perfluorobenzoyl Analogue of Methazolamide. Implications for the Drug Design of Fluorinated Inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/1475636031000119337 ◽

2003 ◽

Vol 18 (4) ◽

pp. 303-308 ◽

Cited By ~ 36

Author(s):

Francesco Abbate ◽

Angela Casini ◽

Andrea Scozzafava ◽

Claudiu T. Supuran

Keyword(s):

Drug Design ◽

Carbonic Anhydrase ◽

Crystallographic Structure ◽

X Ray

Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II–trithiocarbonate adduct—An inhibitor mimicking the sulfonamide and urea binding to the enzyme

10.1016/j.bmcl.2009.11.124 ◽

2010 ◽

Vol 20 (2) ◽

pp. 474-478 ◽

Cited By ~ 67

Author(s):

Claudia Temperini ◽

Andrea Scozzafava ◽

Claudiu T. Supuran

Keyword(s):

Carbonic Anhydrase ◽

Carbonic Anhydrase Ii ◽

X Ray

Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine–benzenesulfonamides acting as carbonic anhydrase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.06.005 ◽

2016 ◽

Vol 24 (16) ◽

pp. 3643-3648 ◽

Cited By ~ 10

Author(s):

Daniela Vullo ◽

Claudiu T. Supuran ◽

Andrea Scozzafava ◽

Giuseppina De Simone ◽

Simona Maria Monti ◽

...

Keyword(s):

Carbonic Anhydrase ◽

X Ray

4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki–Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b01771 ◽

2016 ◽

Vol 59 (2) ◽

pp. 721-732 ◽

Cited By ~ 21

Author(s):

Benedetta Cornelio ◽

Marie Laronze-Cochard ◽

Mariangela Ceruso ◽

Marta Ferraroni ◽

Graham A. Rance ◽

...

Keyword(s):

Carbonic Anhydrase ◽

Enzyme Inhibition ◽

X Ray ◽

Human Carbonic Anhydrase

Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic Anhydrase Inhibitors: Synthesis, Biological Evaluation, and Enzyme−Ligand X-ray Studies

Journal of Medicinal Chemistry ◽

10.1021/jm9014026 ◽

2010 ◽

Vol 53 (6) ◽

pp. 2401-2408 ◽

Cited By ~ 34

Author(s):

Rosaria Gitto ◽

Stefano Agnello ◽

Stefania Ferro ◽

Laura De Luca ◽

Daniela Vullo ◽

...

Keyword(s):

Carbonic Anhydrase ◽

Biological Evaluation ◽

X Ray

Acta Crystallographica Section F Structural Biology and Crystallization Communications ◽

X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes

10.1107/s1744309106020446 ◽

2006 ◽

Vol 62 (7) ◽

pp. 618-622 ◽

Cited By ~ 10

Author(s):

S. Zoë Fisher ◽

Lakshmanan Govindasamy ◽

Nicholas Boyle ◽

Mavis Agbandje-McKenna ◽

David N. Silverman ◽

...

Keyword(s):

Carbonic Anhydrase ◽

Binding Modes ◽

X Ray

Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.12.023 ◽

2009 ◽

Vol 17 (3) ◽

pp. 1214-1221 ◽

Cited By ~ 43

Author(s):

Claudia Temperini ◽

Alessandro Cecchi ◽

Andrea Scozzafava ◽

Claudiu T. Supuran

Keyword(s):

Carbonic Anhydrase ◽

Crystal Structures ◽

Water Molecules ◽

X Ray ◽

The Difference