Design, synthesis and biological evaluation of simplified analogues of MraY inhibitory natural product with rigid scaffold

2021 ◽  
pp. 116556
Author(s):  
Kazuhiro Okamoto ◽  
Aoi Ishikawa ◽  
Ryotaro Okawa ◽  
Kazuki Yamamoto ◽  
Toyotaka Sato ◽  
...  
Keyword(s):  
Natural Product ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of soluble 2,5-diketopiperazines derivatives as potential antifouling agents

RSC Advances ◽  
2015 ◽  
Vol 5 (63) ◽  
pp. 51020-51026 ◽  
Author(s):  
Shengrong Liao ◽  
Ying Xu ◽  
Yong Tang ◽  
Junfeng Wang ◽  
Xuefeng Zhou ◽  
...  
Keyword(s):  
Natural Product ◽  
Environmentally Friendly ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Based on the natural product cyclo-(l-Phe-l-Pro), a library of environmentally friendly 2,5-diketopiperazines were designed, synthesized and showed strong antifouling activities.

Shikonin derivatives as inhibitors of tyrosyl-tRNA synthetase: design, synthesis and biological evaluation

RSC Advances ◽  
2016 ◽  
Vol 6 (86) ◽  
pp. 83003-83010 ◽  
Author(s):  
Han-Yue Qiu ◽  
Peng-Fei Wang ◽  
Zi-Zhen Wang ◽  
Yue-Lin Luo ◽  
Dong-Qing Hu ◽  
...  
Keyword(s):  
Natural Product ◽  
In Silico ◽  
Biological Evaluation ◽  
Trna Synthetase ◽  
Design Synthesis ◽  
Shikonin Derivatives ◽  
Synthesis And Biological Evaluation

A series of novel tyrosyl-tRNA synthetase inhibitors was designed and synthesized as anti-bacteria agents based on natural product shikonin and in silico scaffold modification strategy.

Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors

2015 ◽  
Vol 13 (12) ◽  
pp. 3803-3818 ◽  
Author(s):  
Shuai Song ◽  
Xiaodong Li ◽  
Jing Guo ◽  
Chenzhou Hao ◽  
Yan Feng ◽  
...  
Keyword(s):  
Natural Product ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
P21 Activated Kinase ◽  
Synthesis And Biological Evaluation

Following the screening of an in-house natural product database, 1-phenanthryltetrahydroisoquinoline analogues were synthesized as novel PAK4 inhibitors.

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