Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

Robert M. Garbaccio; Mark E. Fraley; Edward S. Tasber; Christy M. Olson; William F. Hoffman; Kenneth L. Arrington; Maricel Torrent; Carolyn A. Buser; Eileen S. Walsh; Kelly Hamilton; Michael D. Schaber; Christine Fernandes; Robert B. Lobell; Weikang Tao; Vicki J. South; Youwei Yan; Lawrence C. Kuo; Thomayant Prueksaritanont; Donald E. Slaughter; Cathy Shu; David C. Heimbrook; Nancy E. Kohl; Hans E. Huber; George D. Hartman

doi:10.1016/j.bmcl.2005.12.094

Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.12.094 ◽

2006 ◽

Vol 16 (7) ◽

pp. 1780-1783 ◽

Cited By ~ 36

Author(s):

Robert M. Garbaccio ◽

Mark E. Fraley ◽

Edward S. Tasber ◽

Christy M. Olson ◽

William F. Hoffman ◽

...

Keyword(s):

Aqueous Solubility ◽

Kinesin Spindle Protein ◽

Ksp Inhibitors

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Kinesin Spindle Protein (KSP) Inhibitors. Part 2. The Design, Synthesis, and Characterization of 2,4-Diaryl-2,5-dihydropyrrole Inhibitors of the Mitotic Kinesin KSP.

ChemInform ◽

10.1002/chin.200628111 ◽

2006 ◽

Vol 37 (28) ◽

Author(s):

Mark E. Fraley ◽

et al. et al.

Keyword(s):

Synthesis And Characterization ◽

Design Synthesis ◽

Kinesin Spindle Protein ◽

Ksp Inhibitors

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De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.07.029 ◽

2011 ◽

Vol 19 (18) ◽

pp. 5612-5627 ◽

Cited By ~ 17

Author(s):

Cheng Jiang ◽

Lei Yang ◽

Wu-Tong Wu ◽

Qing-Long Guo ◽

Qi-Dong You

Keyword(s):

De Novo ◽

De Novo Design ◽

Biological Evaluation ◽

Design Synthesis ◽

Kinesin Spindle Protein ◽

Ksp Inhibitors ◽

Synthesis And Biological Evaluation

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Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.02.055 ◽

2005 ◽

Vol 15 (8) ◽

pp. 2041-2045 ◽

Cited By ~ 108

Author(s):

Christopher D. Cox ◽

Michael J. Breslin ◽

Brenda J. Mariano ◽

Paul J. Coleman ◽

Carolyn A. Buser ◽

...

Keyword(s):

Selective Inhibitors ◽

Kinesin Spindle Protein ◽

Ksp Inhibitors

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Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.07.074 ◽

2007 ◽

Vol 17 (20) ◽

pp. 5677-5682 ◽

Cited By ~ 30

Author(s):

Anthony J. Roecker ◽

Paul J. Coleman ◽

Swati P. Mercer ◽

John D. Schreier ◽

Carolyn A. Buser ◽

...

Keyword(s):

Design And Synthesis ◽

Kinesin Spindle Protein ◽

Ksp Inhibitors

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Kinesin Spindel Protein (KSP) Inhibitors. Part 3. Synthesis and Evaluation of Phenolic 2,4-Diaryl-2,5-dihydropyrroles with Reduced hERG Binding and Employment of a Phosphate Prodrug Strategy for Aqueous Solubility.

ChemInform ◽

10.1002/chin.200627119 ◽

2006 ◽

Vol 37 (27) ◽

Author(s):

Robert M. Garbaccio ◽

et al. et al.

Keyword(s):

Aqueous Solubility ◽

Ksp Inhibitors

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ChemInform Abstract: Kinesin Spindle Protein (KSP) Inhibitors in Combination with Chemotherapeutic Agents for Cancer Therapy

ChemInform ◽

10.1002/chin.201352267 ◽

2013 ◽

Vol 44 (52) ◽

pp. no-no

Author(s):

Hualong Song ◽

Shanshan Zhou ◽

Rubing Wang ◽

Shaoshun Li

Keyword(s):

Cancer Therapy ◽

Chemotherapeutic Agents ◽

Kinesin Spindle Protein ◽

Ksp Inhibitors

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Kinesin Spindle Protein (KSP) Inhibitors. Part 4. Structure-Based Design of 5-Alkylamino-3,5-diaryl-4,5-dihydropyrazoles as Potent, Water-Soluble Inhibitors of the Mitotic Kinesin KSP.

ChemInform ◽

10.1002/chin.200637115 ◽

2006 ◽

Vol 37 (37) ◽

Author(s):

Christopher D. Cox ◽

et al. et al.

Keyword(s):

Water Soluble ◽

Kinesin Spindle Protein ◽

Ksp Inhibitors

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Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.07.046 ◽

2007 ◽

Vol 17 (19) ◽

pp. 5390-5395 ◽

Cited By ~ 20

Author(s):

Paul J. Coleman ◽

John D. Schreier ◽

Christopher D. Cox ◽

Mark E. Fraley ◽

Robert M. Garbaccio ◽

...

Keyword(s):

Design And Synthesis ◽

Kinesin Spindle Protein ◽

Ksp Inhibitors

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Kinesin Spindle Protein (KSP) Inhibitors in Combination with Chemotherapeutic Agents for Cancer Therapy

ChemMedChem ◽

10.1002/cmdc.201300228 ◽

2013 ◽

Vol 8 (11) ◽

pp. 1736-1749 ◽

Cited By ~ 10

Author(s):

Hualong Song ◽

Shanshan Zhou ◽

Rubing Wang ◽

Shaoshun Li

Keyword(s):

Cancer Therapy ◽

Chemotherapeutic Agents ◽

Kinesin Spindle Protein ◽

Ksp Inhibitors

Download Full-text

Kinesin Spindle Protein (KSP) Inhibitors with 2,3-Fused Indole Scaffolds

Journal of Medicinal Chemistry ◽

10.1021/jm100476d ◽

2010 ◽

Vol 53 (13) ◽

pp. 5054-5058 ◽

Cited By ~ 41

Author(s):

Shinya Oishi ◽

Toshiaki Watanabe ◽

Jun-ichi Sawada ◽

Akira Asai ◽

Hiroaki Ohno ◽

...

Keyword(s):

Kinesin Spindle Protein ◽

Ksp Inhibitors

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