Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity

Straight Chain ◽

Evaluation of the In vitro and In vivo Antitumor Activity of Histone Deacetylase Inhibitors for the Therapy of Retinoblastoma

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-07-4836 ◽

2008 ◽

Vol 14 (10) ◽

pp. 3113-3123 ◽

Cited By ~ 47

Author(s):

Clifton Lee Dalgard ◽

Kurtis R. Van Quill ◽

Joan M. O'Brien

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.01.041 ◽

2009 ◽

Vol 19 (5) ◽

pp. 1403-1408 ◽

Cited By ~ 16

Author(s):

Haishan Wang ◽

Niefang Yu ◽

Hongyan Song ◽

Dizhong Chen ◽

Yong Zou ◽

...

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

Design Synthesis ◽

Sar Studies ◽

N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity: Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)

Journal of Medicinal Chemistry ◽

10.1021/jm030235w ◽

2003 ◽

Vol 46 (21) ◽

pp. 4609-4624 ◽

Cited By ~ 97

Author(s):

Stacy W. Remiszewski ◽

Lidia C. Sambucetti ◽

Kenneth W. Bair ◽

John Bontempo ◽

David Cesarz ◽

...

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

In Vivo Antitumor Activity ◽

Activity Discovery ◽

Methyl Phenyl

A Novel Series of Potent and Selective Ketone Histone Deacetylase Inhibitors with Antitumor Activity in Vivo

Journal of Medicinal Chemistry ◽

10.1021/jm800079s ◽

2008 ◽

Vol 51 (8) ◽

pp. 2350-2353 ◽

Cited By ~ 38

Author(s):

Philip Jones ◽

Sergio Altamura ◽

Raffaele De Francesco ◽

Odalys Gonzalez Paz ◽

Olaf Kinzel ◽

...

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

Histone Deacetylase Inhibitors

6P In vivo antitumor activity of FK-A11, a depsipeptide analog targeting both histone deacetylase and phosphoinositide 3-kinase

Annals of Oncology ◽

10.1093/annonc/mdv517.06 ◽

2015 ◽

Vol 26 ◽

pp. ix1

Author(s):

K. Saijo ◽

K. Narita ◽

T. Katoh ◽

C. Ishioka

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

In Vivo Antitumor Activity ◽

Phosphoinositide 3 Kinase

Synthesis and Biological Evaluation of 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indoles as Potent Histone Deacetylase Inhibitors with Antitumor Activity in Vivo

Journal of Medicinal Chemistry ◽

10.1021/jm300197a ◽

2012 ◽

Vol 55 (8) ◽

pp. 3777-3791 ◽

Cited By ~ 35

Author(s):

Mei-Jung Lai ◽

Han-Li Huang ◽

Shiow-Lin Pan ◽

Yi-Min Liu ◽

Chieh-Yu Peng ◽

...

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

Synthesis And Biological Evaluation

Biological Evaluation ◽

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.96.8.4592 ◽

1999 ◽

Vol 96 (8) ◽

pp. 4592-4597 ◽

Cited By ~ 478

Author(s):

A. Saito ◽

T. Yamashita ◽

Y. Mariko ◽

Y. Nosaka ◽

K. Tsuchiya ◽

...

Keyword(s):

Antitumor Activity ◽

Histone Deacetylase ◽

Human Tumors ◽

Synthetic Inhibitor ◽

Faculty Opinions recommendation of The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726730887.793523065 ◽

2016 ◽

Author(s):

David Kranz

Keyword(s):

Antitumor Activity ◽

Antigen Receptors ◽

Chimeric Antigen Receptors ◽

ChemInform Abstract: SYNTHESIS AND IN VIVO ANTITUMOR ACTIVITY OF POTENTIAL 5-FLUOROURACIL PRODRUGS

Chemischer Informationsdienst ◽

10.1002/chin.198305341 ◽

1983 ◽

Vol 14 (5) ◽

Author(s):

A. ROSOWSKY ◽

S.-H. KIM ◽

D. TRITES ◽

M. WICK

Keyword(s):

Antitumor Activity ◽

ChemInform Abstract: METHOTREXATE ANALOGS. 22. SYNTHESIS, DIHYDROFOLATE REDUCTASE AFFINITY, CYTOTOXICITY, AND IN VIVO ANTITUMOR ACTIVITY OF SOME PUTATIVE DEGRADATION PRODUCTS OF METHOTREXATE-POLY(L-LYSINE) CONJUGATES

Chemischer Informationsdienst ◽

10.1002/chin.198449291 ◽

1984 ◽

Vol 15 (49) ◽

Author(s):

A. ROSOWSKY ◽

R. A. FORSCH ◽

J. H. FREISHEIM ◽

J. GALIVAN ◽

M. WICK

Keyword(s):

Antitumor Activity ◽

Dihydrofolate Reductase ◽

Degradation Products ◽