A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity

2021 ◽  
Vol 36 ◽  
pp. 127790
Author(s):  
Tetsuji Noguchi ◽  
Yuma Umezaki ◽  
Rieko Takano ◽  
Teppei Fujimoto ◽  
Yuki Domon ◽  
...  
Keyword(s):  
Opioid Activity

Evaluation of New Compounds for Opioid Activity: Annual Report (1993)

1994 ◽  
Author(s):  
J. C. Woods ◽  
◽  
C. P. France ◽  
F. Medzihradsky ◽  
C. B. Smith ◽  
...  
Keyword(s):  
Annual Report ◽  
Opioid Activity ◽  
New Compounds

Preparation and properties of three analogues of [5-leucine]enkephalin, substrates for enzyme conversion studies

1985 ◽  
Vol 50 (6) ◽  
pp. 1329-1334
Author(s):  
Jaroslav Vičar ◽  
Linda Servítová ◽  
Martin Flegel ◽  
Karel Hauzer ◽  
Tomislav Barth
Keyword(s):  
High Pressure ◽  
Liquid Chromatography ◽  
Guinea Pig ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Guinea Pig Ileum ◽  
Opioid Activity ◽  
C Terminus ◽  
N Terminus ◽  
Fragment Condensation

Analogues of [5-Leu]enkephalin, prolonged by methionine on the N-terminus or, by lysine or methionine on the C-terminus were prepared by fragment condensation, purified by ion exchange chromatography or high-pressure liquid chromatography. The substances were characterised by their opioid activity in a test on guinea-pig ileum in comparison with the activity of [5-Leu]enkephalin.

Peripheral and central opioid activity in the analgesic potency of morphine in rats

1989 ◽  
Vol 21 ◽  
pp. 37-38
Author(s):  
T. Catti ◽  
C. Parenti ◽  
C. Spadaro ◽  
R. Arrigo-Reina
Keyword(s):  
Opioid Activity ◽  
Analgesic Potency

Synthesis and Opioid Activity of Novel 6-ketolevorphanol Derivatives

2013 ◽  
Vol 9 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Zsuzsanna Gyulai ◽  
Antal Udvardy ◽  
Attila Cs. Benyei ◽  
Jakub Fichna ◽  
Katarzyna Gach ◽  
...  
Keyword(s):  
Opioid Activity

Synthesis and opioid activity of novel tetrapeptides analogous to sequence (1–4) of dermorphin

Neuropeptides ◽  
1998 ◽  
Vol 32 (4) ◽  
pp. 333-338
Author(s):  
T Naqvi ◽  
R Raghubir ◽  
W Haq ◽  
A Tripathi ◽  
G.K Patnaik ◽  
...  
Keyword(s):  
Opioid Activity

Menstrual Migraine is Not Pathogenetically Related to Premenstrual Syndrome

Cephalalgia ◽  
1994 ◽  
Vol 14 (6) ◽  
pp. 411-412 ◽  
Author(s):  
VK Gupta
Keyword(s):  
Premenstrual Syndrome ◽  
Side Effect ◽  
Biological Significance ◽  
Menstrual Migraine ◽  
Adaptive Mechanism ◽  
Primary Event ◽  
Epidemiological Evidence ◽  
Endogenous Opioid ◽  
Opioid Activity ◽  
The Common

Facchinetti and colleagues present epidemiological evidence regarding comorbidity between menstrual migraine and premenstrual syndrome, and suggest that premenstural symptoms should be incorporated in the diagnostic criteria for menstrual migraine (1). The crux of the matter, however, should be the concern regarding the nature or biological significance of the common neuroendocrine link of transient and cyclic failure of endogenous opioid activity in both premenstrual syndrome and menstrual migraine patients. Is this a primary event of pathogenetic importance (which would merit inclusion in the definition) or the concomitant side effect of a carefully orchestrated adaptive mechanism?

Synthesis and Opioid Activity of Conformationally Constrained Dynorphin A Analogues. 2.1Conformational Constraint in the “Address” Sequence†,‡

1997 ◽  
Vol 40 (8) ◽  
pp. 1211-1218 ◽  
Author(s):  
Seksiri Arttamangkul ◽  
Jane E. Ishmael ◽  
Thomas F. Murray ◽  
David K. Grandy ◽  
Gary E. DeLander ◽  
...  
Keyword(s):  
Dynorphin A ◽  
Opioid Activity ◽  
Conformationally Constrained

Agonist and antagonist opioid activity of axial and equatorial conformations of S-methyl- and S-allyl-morphinans

1994 ◽  
Vol 258 (1-2) ◽  
pp. 111-118 ◽  
Author(s):  
Simon Lemaire ◽  
Bernard Belleau ◽  
François B. Jolicoeur
Keyword(s):  
Opioid Activity ◽  
Agonist And Antagonist
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